Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in
the central nervous system (CNS); however, residual glutamate in the extracellular space is …

Excitotoxicity is a phenomenon that describes the toxic actions of excitatory
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …

Rapid removal of glutamate from the extracellular space is required for the survival and
normal function of neurons. Although glutamate transporters are expressed by all CNS cell …

In order for the brain to use the common amino acid glutamate as a neurotransmitter, it has
been necessary to introduce a series of innovations that greatly restrict the availability of …

In the mammalian brain, a family of sodium-dependent transporters maintains low
extracellular glutamate and shapes excitatory signaling. The bulk of this activity is mediated …

Autism spectrum disorder (ASD) is characterised by deficits in the ability to socialise,
communicate and use imagination, and displays of stereotypical behaviour. It is widely …

Plasma amino acid levels were measured in autistic and Asperger syndrome patients, their
siblings, and parents. The results were compared with values from age-matched controls …

Glutamate released at synapses in the CA1 region of the hippocampus escapes the synaptic
cleft and activates extrasynaptic targets; it also may “spill over” into neighboring synapses …

In addition to maintaining the extracellular glutamate concentration at low ambient levels,
high-affinity glutamate transporters play a direct role in synaptic transmission by speeding …

A low concentration (10 nM) of adenosine potentiated hippocampal neuronal activity via A2a
adenosine receptors without affecting presynaptic glutamate release or postsynaptic …