Peptidoglycan recognition proteins: pleiotropic sensors and effectors of antimicrobial defences

J Royet, R Dziarski - Nature Reviews Microbiology, 2007 - nature.com
Peptidoglycan recognition proteins (PGRPs) are innate immunity molecules that are present
in most invertebrate and vertebrate animals. All PGRPs function in antimicrobial defence …

The peptidoglycan recognition proteins (PGRPs)

R Dziarski, D Gupta - Genome biology, 2006 - Springer
Peptidoglycan recognition proteins (PGRPs) are innate immunity molecules present in
insects, mollusks, echinoderms, and vertebrates, but not in nematodes or plants. PGRPs …

Mammalian peptidoglycan recognition proteins (PGRPs) in innate immunity

R Dziarski, D Gupta - Innate immunity, 2010 - journals.sagepub.com
Peptidoglycan recognition proteins (PGRPs or PGLYRPs) are innate immunity proteins that
are conserved from insects to mammals, recognize bacterial peptidoglycan, and function in …

Novel peptide therapeutics for treatment of infections

PCF Oyston, MA Fox, SJ Richards… - Journal of medical …, 2009 - microbiologyresearch.org
As antibiotic resistance increases worldwide, there is an increasing pressure to develop
novel classes of antimicrobial compounds to fight infectious disease. Peptide therapeutics …

Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins

JH Lim, MS Kim, HE Kim, T Yano, Y Oshima… - Journal of Biological …, 2006 - ASBMB
Drosophila peptidoglycan recognition protein (PGRP)-LCx and-LCa are receptors that
preferentially recognize meso-diaminopimelic acid (DAP)-type peptidoglycan (PGN) present …

Peptidoglycan recognition proteins of the innate immune system

R Guan, RA Mariuzza - Trends in microbiology, 2007 - cell.com
Peptidoglycan (PGN) is the major component of bacterial cell walls and one of the main
microbial products recognized by the innate immune system. PGN recognition is mediated …

Peptidoglycan: a critical activator of the mammalian immune system during infection and homeostasis

MT Sorbara, DJ Philpott - Immunological reviews, 2011 - Wiley Online Library
Peptidoglycan is a conserved structural component of the bacterial cell wall with molecular
motifs unique to bacteria. The mammalian immune system takes advantage of these …

Structural basis for peptidoglycan binding by peptidoglycan recognition proteins

R Guan, A Roychowdhury, B Ember… - Proceedings of the …, 2004 - National Acad Sciences
Peptidoglycan (PGN) recognition proteins (PGRPs) are pattern-recognition receptors of the
innate immune system that bind and, in some cases, hydrolyze bacterial PGNs. We …

Mammalian PGRPs: novel antibacterial proteins

R Dziarski, D Gupta - Cellular microbiology, 2006 - Wiley Online Library
Peptidoglycan recognition proteins (PGRPs) are innate immunity molecules conserved from
insects to mammals. Insects have up to 19 PGRPs, which activate Toll or Imd signal …

Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid

FR Salsbury Jr, ST Knutson, LB Poole… - Protein …, 2008 - Wiley Online Library
Cysteine sulfenic acid (Cys‐SOH), a reversible modification, is a catalytic intermediate at
enzyme active sites, a sensor for oxidative stress, a regulator of some transcription factors …