Engineering and emerging applications of artificial metalloenzymes with whole cells

M Wittwer, U Markel, J Schiffels, J Okuda, DF Sauer… - Nature Catalysis, 2021 - nature.com
The field of artificial metalloenzymes (ArMs) is rapidly growing and ArMs are attracting
increasing attention, for example, in the fields of biosensing and drug therapy. Protein …

Nature inspired catalysts: a review on electroactive microorganism-based catalysts for electrochemical applications

S Bajracharya, B Bian, R Jimenez-Sandoval… - Electrochimica …, 2024 - Elsevier
The pursuit of efficient and sustainable electrochemical systems, that can generate green
fuels and chemicals, stands as a primary contemporary challenge for sustaining a circular …

Design of artificial enzymes: insights into protein scaffolds.

S Hanreich, E Bonandi, I Drienovská - Chembiochem: a European …, 2022 - europepmc.org
The design of artificial enzymes has emerged as a promising tool for the generation of
potent biocatalysts able to promote new-to-nature reactions with improved catalytic …

A Dual‐Metal‐Catalyzed Sequential Cascade Reaction in an Engineered Protein Cage

P Ebensperger, M Zmyslia, P Lohner… - Angewandte Chemie …, 2023 - Wiley Online Library
Herein, we describe the creation of an artificial protein cage housing a dual‐metal‐tagged
guest protein that catalyzes a linear, two‐step sequential cascade reaction. The guest …

Chemoenzymatic cascade for stilbene production from cinnamic acid catalyzed by ferulic acid decarboxylase and an artificial metathease

MAS Mertens, DF Sauer, U Markel, J Schiffels… - Catalysis Science & …, 2019 - pubs.rsc.org
We report the preparation of symmetrical stilbene derivatives in a two-step one-pot cascade
reaction based on enzymatic decarboxylation of cinnamic acid followed by olefin cross …

FhuA: From Iron-Transporting Transmembrane Protein to Versatile Scaffolds through Protein Engineering

DF Sauer, U Markel, J Schiffels, J Okuda… - Accounts of Chemical …, 2023 - ACS Publications
Conspectus Protein engineering has emerged as a powerful methodology to tailor the
properties of proteins. It empowers the design of biohybrid catalysts and materials, thereby …

Artificial metalloenzymes: From selective chemical transformations to biochemical applications

T Himiyama, Y Okamoto - Molecules, 2020 - mdpi.com
Artificial metalloenzymes (ArMs) comprise a synthetic metal complex in a protein scaffold.
ArMs display performances combining those of both homogeneous catalysts and …

A combined bio-chemical synthesis route for 1-octene sheds light on rhamnolipid structure

T Tiso, DF Sauer, K Beckerle, CC Blesken, J Okuda… - Catalysts, 2020 - mdpi.com
Here we report a chemoenzymatic approach to synthesize 1-octene from carbohydrates via
ethenolysis of rhamnolipids. Rhamnolipids synthesized by P. putida contain a double bond …

[HTML][HTML] Grubbs-Hoveyda catalysts conjugated to a β-barrel protein: Effect of halide substitution on aqueous olefin metathesis activity

AA Ingram, D Wang, U Schwaneberg… - Journal of Inorganic …, 2024 - Elsevier
The effect of halide substitution in Grubbs-Hoveyda II catalysts (GHII catalysts) embedded in
the engineered β-barrel protein nitrobindin (NB4exp) on metathesis activity in aqueous …

4‐Halomethyl‐Substituted Imidazolium Salts: A Versatile Platform for the Synthesis of Functionalized NHC Precursors

DV Pasyukov, MA Shevchenko… - Chemistry–An Asian …, 2024 - Wiley Online Library
N, N′‐Diarylimidazolium salts containing haloalkyl functional groups that are reactive with
various nucleophiles are considered to be promising reagents for the preparation of …