HLA-associated autoimmune diseases likely arise from T-cell-mediated autoimmune
responses against certain self-peptides from the broad HLA-presented immunopeptidomes …

Histological samples of autopsy or biopsy tissue provide the best available evidence that
autoreactive T cells are involved in the immunopathogenesis of many autoimmune …

Abstract αβ T cell antigen receptors (TCRs) bind complexes of peptide and major
histocompatibility complex (pMHC) with low affinity, which poses a considerable challenge …

Spontaneous autoimmune diabetes development in NOD mice requires both CD8+ and
CD4+ T cells. Three pathogenic CD8+ T cell populations (represented by the G9C8, 8.3, and …

The conceptual and technical approaches that led to the explosive growth of combinatorial
chemistry began approximately 20 years ago. In the past decade, combinatorial chemistry …

Abstract Hitting the SPOT: In 1992, Ronald Frank published the first seminal paper on
simultaneous parallel synthesis of multiple peptides on filter paper. He defined the approach …

The development of DNA microarray technology a decade ago led to the establishment of
functional genomics as one of the most active and successful scientific disciplines today …

Studies on the elucidation of the specificity of the T cell receptor (TCR) at the antigen and
peptide level have contributed to the current understanding of T cell cross-reactivity …

Viral infections play a role in shaping and maintaining the peripheral T-cell repertoire, as
well as in the initiation of autoimmune response via mechanisms of molecular mimicry. In …

T lymphocytes play important roles not only in infectious diseases and autoimmunity, but
also in immune responses against tumors. For many of these disorders, the relevant target …