Intrinsically disordered proteins (IDPs) constitute a broad set of proteins with few uniting and
many diverging properties. IDPs—and intrinsically disordered regions (IDRs) interspersed …

Understanding the thermodynamic stability and metastability of materials can help us to, for
example, gauge whether crystalline polymorphs in pharmaceutical formulations are likely to …

Pharmaceutical cocrystals represent an emergent class of successful materials designed
based on crystal engineering principles, in which the limitations of the extant drugs are …

Emerging evidences have suggested that liquid–liquid phase separation (LLPS) of proteins
plays a vital role both in a wide range of biological processes and in related diseases …

Biomolecular condensation processes are increasingly recognized as a fundamental
mechanism that living cells use to organize biomolecules in time and space. These …

Structural bioinformatics suffers from the lack of interfaces connecting biological structures
and machine learning methods, making the application of modern neural network …

Traditionally, our understanding of how proteins operate and how evolution shapes them is
based on two main data sources: the overall protein fold and the protein amino acid …

Protein phase transitions (PPTs) from the soluble state to a dense liquid phase (forming
droplets via liquid–liquid phase separation) or to solid aggregates (such as amyloids) play …

Liquid–liquid phase separation (LLPS) and the solid aggregate (also referred to as amyloid
aggregates) formation of proteins, have gained significant attention in recent years due to …

Liquid–liquid phase separation (LLPS) of proteins and nucleic acids underlies the formation
of biomolecular condensates in cell. Dysregulation of protein LLPS is closely implicated in a …