Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies

S Paul, E Candelario-Jalil - Experimental neurology, 2021 - Elsevier
Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Pathophysiology of blood–brain barrier permeability throughout the different stages of ischemic stroke and its implication on hemorrhagic transformation and recovery

S Bernardo-Castro, JA Sousa, A Brás, C Cecília… - Frontiers in …, 2020 - frontiersin.org
The blood–brain barrier (BBB) is a dynamic interface responsible for maintaining the central
nervous system homeostasis. Its unique characteristics allow protecting the brain from …

Emerging role of non-coding RNAs in neuroinflammation mediated by microglia and astrocytes

R Yang, B Yang, W Liu, C Tan, H Chen… - Journal of …, 2023 - Springer
Neuroinflammation has been implicated in the initiation and progression of several central
nervous system (CNS) disorders, including Alzheimer's disease, Parkinson's disease …

Bone marrow mesenchymal stem cell-derived exosomes carrying long noncoding RNA ZFAS1 alleviate oxidative stress and inflammation in ischemic stroke by …

H Yang, J Chen - Metabolic brain disease, 2022 - Springer
Background/aim Bone marrow mesenchymal stem cell (BMSC)-derived exosomes can
prevent oxidative stress and inflammation in cerebral ischemia-reperfusion injury. This study …

Role of regulatory non-coding RNAs in traumatic brain injury

S Li, N Qiu, A Ni, MH Hamblin, KJ Yin - Neurochemistry international, 2024 - Elsevier
Traumatic brain injury (TBI) is a potentially fatal health event that cannot be predicted in
advance. After TBI occurs, it can have enduring consequences within both familial and …

P2Y6 receptor activation aggravates NLRP3-dependent microglial pyroptosis via downregulation of the PI3K/AKT pathway in a mouse model of intracerebral …

Y Li, H Tu, S Zhang, Z Ding, G Wu, J Piao, D Lv… - Molecular …, 2024 - Springer
Pro-inflammatory signals generated after intracerebral hemorrhage (ICH) trigger a form of
regulated cell death known as pyroptosis in microglia. White matter injury (WMI) refers to the …

Astrocytic p75NTR expression provoked by ischemic stroke exacerbates the blood–brain barrier disruption

X Qin, J Wang, S Chen, G Liu, C Wu, Q Lv, X He, X Bai… - Glia, 2022 - Wiley Online Library
The disruption of the blood–brain barrier (BBB) plays a critical role in the pathology of
ischemic stroke. p75 neurotrophin receptor (p75NTR) contributes to the disruption of the …

Blood-brain barrier dysfunction in CNS disorders and putative therapeutic targets: an overview

SR Archie, A Al Shoyaib, L Cucullo - Pharmaceutics, 2021 - mdpi.com
The blood-brain barrier (BBB) is a fundamental component of the central nervous system
(CNS). Its functional and structural integrity is vital to maintain the homeostasis of the brain …

Calcium/calmodulin–dependent protein kinase II in cerebrovascular diseases

X Zhang, J Connelly, ES Levitan, D Sun… - Translational Stroke …, 2021 - Springer
Cerebrovascular disease is the most common life-threatening and debilitating condition that
often leads to stroke. The multifunctional calcium/calmodulin-dependent protein kinase II …