The development of increasingly efficient and cost-effective high throughput DNA
sequencing techniques has enhanced the possibility of studying complex microbial systems …

It is challenging to associate features such as human health outcomes, diet, environmental
conditions, or other metadata to microbial community measurements, due in part to their …

The microbiome represents a hidden world of tiny organisms populating not only our
surroundings but also our own bodies. By enabling comprehensive profiling of these …

Many methods have been developed for statistical analysis of microbial community profiles,
but due to the complex nature of typical microbiome measurements (eg sparsity, zero …

Accurate prediction of the host phenotype from a metagenomic sample and identification of
the associated microbial markers are important in understanding potential host-microbiome …

Background In microbiome disease association studies, it is a fundamental task to test which
microbes differ in their abundance between groups. Yet, consensus on suitable or optimal …

A major challenge in managing and engineering microbial communities is determining
whether and how microbial community responses to environmental alterations can be …

A critical challenge in microbiome data analysis is the existence of many non-biological
zeros, which distort taxon abundance distributions, complicate data analysis, and jeopardize …

Many modern applications seek to understand the relationship between an outcome
variable $ Y $ and a covariate $ X $ in the presence of a (possibly high-dimensional) …

Background Irritable bowel syndrome (IBS), a disorder of the gut–brain axis, is affected by
the microbiome. Microbial studies in pediatric IBS, especially for centrally mediated …