Flow in fetoplacental-like microvessels in vitro enhances perfusion, barrier function, and matrix stability
M Cherubini, S Erickson, P Padmanaban… - Science …, 2023 - science.org
Proper placental vascularization is vital for pregnancy outcomes, but assessing it with
animal models and human explants has limitations. We introduce a 3D in vitro model of …
animal models and human explants has limitations. We introduce a 3D in vitro model of …
Pharmacological and molecular mechanisms of miRNA-based therapies for targeting cardiovascular dysfunction
Advances in understanding gene expression regulation through epigenetic mechanisms
have contributed to elucidating the regulatory mechanisms of noncoding RNAs as …
have contributed to elucidating the regulatory mechanisms of noncoding RNAs as …
Epigenetic regulation by hypoxia, N‐acetylcysteine and hydrogen sulphide of the fetal vasculature in growth restricted offspring: A study in humans and chicken …
BJ Krause, AA Paz, TAC Garrud… - The Journal of …, 2024 - Wiley Online Library
Fetal growth restriction (FGR) is a common outcome in human suboptimal gestation and is
related to prenatal origins of cardiovascular dysfunction in offspring. Despite this, therapy of …
related to prenatal origins of cardiovascular dysfunction in offspring. Despite this, therapy of …
Maternal obesity and high leptin levels prime pro-inflammatory pathways in human cord blood leukocytes
BJ Krause, FA Vega-Tapia, G Soto-Carrasco, I Lefever… - Placenta, 2023 - Elsevier
Introduction Maternal obesity alters the immune function in the offspring. We hypothesize
that maternal obesity and pro-inflammatory pathways induce leptin-related genes in …
that maternal obesity and pro-inflammatory pathways induce leptin-related genes in …
In vitro Examination of Piezo1-TRPV4 Dynamics: Implications for Placental Endothelial Function in Normal and Preeclamptic Pregnancies
HH Allerkamp, AI Bondarenko… - … of Physiology-Cell …, 2024 - journals.physiology.org
Mechanosensation is essential for endothelial cell (EC) function, which is compromised in
early-onset preeclampsia (EPE), impacting offspring health. The ion channels Piezo-type …
early-onset preeclampsia (EPE), impacting offspring health. The ion channels Piezo-type …
Transcriptional Profiling of Human Endothelial Cells Unveils PIEZO1 and Mechanosensitive Gene Regulation by Prooxidant and Inflammatory Inputs
GA Arenas, JG Valenzuela, E Peñaloza, AA Paz… - Antioxidants, 2023 - mdpi.com
PIEZO1 is a mechanosensitive cation channel implicated in shear stress-mediated
endothelial-dependent vasorelaxation. Since altered shear stress patterns induce a pro …
endothelial-dependent vasorelaxation. Since altered shear stress patterns induce a pro …
[PDF][PDF] Exploring the Lifeline: Unpacking the Complexities of Placental Vascular Function in Normal and Preeclamptic Pregnancies
C Schliefsteiner, C Wadsack… - Comprehensive …, 2011 - placentalab.science
The proper development and function of the placenta are essential for the success of
pregnancy and the well-being of both the fetus and the mother. Placental vascular function …
pregnancy and the well-being of both the fetus and the mother. Placental vascular function …