[HTML][HTML] Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses
JT Ladner, SN Henson, AS Boyle… - Cell Reports …, 2021 - cell.com
The SARS-CoV-2 proteome shares regions of conservation with endemic human
coronaviruses (CoVs), but it remains unknown to what extent these may be cross …
coronaviruses (CoVs), but it remains unknown to what extent these may be cross …
PepSeq: a fully in vitro platform for highly multiplexed serology using customizable DNA-barcoded peptide libraries
PepSeq is an in vitro platform for building and conducting highly multiplexed proteomic
assays against customizable targets by using DNA-barcoded peptides. Starting with a pool …
assays against customizable targets by using DNA-barcoded peptides. Starting with a pool …
Cell-free translation of peptides and proteins: from high throughput screening to clinical production
CJ Murray, R Baliga - Current opinion in chemical biology, 2013 - Elsevier
In the past decade, in vitro transcription/translation technologies have emerged as discovery
tools for screening large protein expression libraries, for the selection of engineered …
tools for screening large protein expression libraries, for the selection of engineered …
Identification of protease specificity by combining proteome-derived peptide libraries and quantitative proteomics
ML Biniossek, M Niemer, K Maksimchuk… - Molecular & cellular …, 2016 - ASBMB
We present protease specificity profiling based on quantitative proteomics in combination
with proteome-derived peptide libraries. Peptide libraries are generated by endoproteolytic …
with proteome-derived peptide libraries. Peptide libraries are generated by endoproteolytic …
High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome
SA Shiryaev, AV Chernov, VS Golubkov, ER Thomsen… - PloS one, 2013 - journals.plos.org
Background There is a growing appreciation of the role of proteolytic processes in human
health and disease, but tools for analysis of such processes on a proteome-wide scale are …
health and disease, but tools for analysis of such processes on a proteome-wide scale are …
[HTML][HTML] COVID-19 vaccination elicits an evolving, cross-reactive antibody response to epitopes conserved with endemic coronavirus spike proteins
The COVID-19 pandemic has triggered the first widespread vaccination campaign against a
coronavirus. Many vaccinated subjects are previously naive to SARS-CoV-2; however …
coronavirus. Many vaccinated subjects are previously naive to SARS-CoV-2; however …
[HTML][HTML] Profiling cells with DELs: Small molecule fingerprinting of cell surfaces
J Deng, S Belyanskaya, N Prabhu, C Arico-Muendel… - SLAS Discovery, 2024 - Elsevier
DNA-encoded small molecule library technology has recently emerged as a new paradigm
for identifying ligands against drug targets. To date, it has been used to identify ligands …
for identifying ligands against drug targets. To date, it has been used to identify ligands …
High-throughput multiplexed peptide-centric profiling illustrates both substrate cleavage redundancy and specificity in the MMP family
Matrix metalloproteinases (MMPs) play incompletely understood roles in health and
disease. Knowing the MMP cleavage preferences is essential for a better understanding of …
disease. Knowing the MMP cleavage preferences is essential for a better understanding of …
Substrate cleavage profiling suggests a distinct function of Bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation …
SA Shiryaev, AG Remacle, AV Chernov… - Journal of Biological …, 2013 - ASBMB
Enterotoxigenic anaerobic Bacteroides fragilis is a significant source of inflammatory
diarrheal disease and a risk factor for colorectal cancer. Two distinct metalloproteinase types …
diarrheal disease and a risk factor for colorectal cancer. Two distinct metalloproteinase types …
Comprehensive analysis of transglutaminase substrate preference by cDNA display coupled with next-generation sequencing and bioinformatics
J Damnjanović, N Odake, J Fan, M Camagna, B Jia… - Scientific Reports, 2022 - nature.com
Abstract cDNA display is an in vitro display technology based on a covalent linkage between
a protein and its corresponding mRNA/cDNA, widely used for the selection of proteins and …
a protein and its corresponding mRNA/cDNA, widely used for the selection of proteins and …