Genome architecture has proven to be critical in determining gene regulation across almost
all domains of life. While many of the key components and mechanisms of eukaryotic …

Once described as mere “bags of enzymes,” bacterial cells are in fact highly organized, with
many macromolecules exhibiting nonuniform localization patterns. Yet the physical and …

Post-translational modification (PTM) of histones has been investigated in eukaryotes for
years, revealing its widespread occurrence and functional importance. Many PTMs affect …

The bacterial nucleoid-associated protein Fis regulates diverse reactions by bending DNA
and through DNA-dependent interactions with other control proteins and enzymes. In …

Fis, the most abundant DNA-binding protein in Escherichia coli during rapid growth, has
been suspected to play an important role in defining nucleoid structure. Using bulk-phase …

Fis protein is a nucleoid-associated protein that plays many roles in transcriptional
regulation and DNA site-specific recombination. In contrast to the naïve expectation based …

This chapter focuses on the major nucleoid‐associated proteins and summarizes one's
current knowledge of how these proteins contribute to the structure of the nucleoid and …

Fis is a versatile transactivator that functions at many different promoters. Fis activates
transcription at the RpoS-dependent proP P2 promoter when bound to a site that overlaps …

Reversible site‐specific inversions of DNA segments occur within the genomes of many
bacteria and their phages. These reactions are catalyzed by a dedicated recombinase and …

Bacteria represent the vast majority of biological diversity found on Earth. In this review, we
focus on selected aspects of their genetic material, those providing insight into structural …