Babesiosis is a disease with a world-wide distribution affecting many species of mammals
principally cattle and man. The major impact occurs in the cattle industry where bovine …

The ubiquitin/proteasome system serves as a regulated protein degradation pathway in
eukaryotes, and is involved in many cellular processes featuring high protein turnover rates …

Ribosome-targeting antibiotics exert their antimalarial activity on the apicoplast of the
malaria parasite, an organelle of prokaryote origin having essential metabolic functions …

Malaria continues to be a major global health problem, but only a limited arsenal of effective
drugs is available. None of the antimalarial compounds commonly used clinically kill mature …

Background The emergence and spread of Plasmodium falciparum resistance to almost all
available antimalarial drugs necessitates the search for new chemotherapeutic compounds …

Causing more than one million deaths annually, tropical malaria is a fundamental threat to
human health worldwide. Successful chemotherapeutic treatment is increasingly …

Artemisinin (ART)-based combination therapies are the most efficacious treatment of
uncomplicated Plasmodium falciparum malaria. Alarmingly, P. falciparum strains have …

The diverse functional roles that proteases play in basic biological processes make them
essential for virtually all organisms. Not surprisingly, proteolysis is also a critical process …

The proteasome plays a vital role throughout the life cycle as Plasmodium parasites quickly
adapt to a new host and undergo a series of morphologic changes during asexual …

Semi-immunity against Pf malaria is based on a combination of cellular and humoral
immune responses. PMNs and IgGs are considered important components of this process …