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Introduction: Desired clinical outcome of pharmacotherapy of brain diseases largely …

The blood–brain barrier (BBB) plays a key role in regulating transport into and out of the
brain. With increasing interest in the role of the BBB in health and disease, there have been …

The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many
pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we …

The blood-brain barrier (BBB) tightly regulates the entry of solutes from blood into the brain
and is disrupted in several neurological diseases. Using Organ-Chip technology, we created …

Microvessels of the blood-brain barrier (BBB) regulate transport into the brain. The highly
specialized brain microvascular endothelial cells, a major component of the BBB, express …

In 2012, we provided the first published evidence that human pluripotent stem cells could be
differentiated to cells exhibiting markers and phenotypes characteristic of the blood–brain …

Background Due to their ability to limitlessly proliferate and specialize into almost any cell
type, human induced pluripotent stem cells (iPSCs) offer an unprecedented opportunity to …

Background The endothelial cells that form the lumen of capillaries and microvessels are an
important component of the blood–brain barrier. Cell phenotype is regulated by transducing …

We have developed a renewable, scalable and transgene free human blood-brain barrier
model, composed of brain endothelial cells (BECs), generated from human amniotic fluid …

Background Pericytes of the blood–brain barrier (BBB) are embedded within basement
membrane between brain microvascular endothelial cells (BMECs) and astrocyte end-feet …