Although most mRNA molecules derived from protein-coding genes are destined to be
translated into functional polypeptides, some are eliminated by cellular quality control …

Cells use messenger RNAs (mRNAs) to ensure the accurate dissemination of genetic
information encoded by DNA. Given that mRNAs largely direct the synthesis of a critical …

Eukaryotic gene expression is constantly controlled by the translation-coupled nonsense-
mediated mRNA decay (NMD) pathway. Aberrant translation termination leads to NMD …

All RNA species in yeast cells are subject to turnover. Work over the past 20 years has
defined degradation mechanisms for messenger RNAs, transfer RNAs, ribosomal RNAs …

The nonsense-mediated mRNA decay (NMD) pathway is well known as a translation-
coupled quality control system that recognizes and degrades aberrant mRNAs with …

Fully assembled ribosomes exist in two populations: polysomes and monosomes. While the
former has been studied extensively, to what extent translation occurs on monosomes and …

Cells routinely make mistakes. Some mistakes are encoded by the genome and may
manifest as inherited or acquired diseases. Other mistakes occur because metabolic …

Nonsense‐mediated mRNA decay (NMD) was originally coined to define a quality control
mechanism that targets mRNAs with truncated open reading frames due to the presence of a …

Alternative splicing (AS) strongly affects gene expression by generating protein isoform
diversity. However, up to one-third of human AS events create a premature termination …

RNA decay is usually mediated by protein complexes and can occur in specific foci such as
P-bodies in the cytoplasm of eukaryotes. In human mitochondria nothing is known about the …