Neurons have more extended and complex shapes than other cells and consequently face a
greater challenge in distributing and maintaining mitochondria throughout their arbors …

Mitochondria are associated with various cellular activities critical to homeostasis,
particularly in the nervous system. The plastic architecture of the mitochondrial network and …

Melatonin has been speculated to be mainly synthesized by mitochondria. This speculation
is supported by the recent discovery that aralkylamine N-acetyltransferase/serotonin N …

Mammalian genes were long thought to be constrained within somatic cells in most cell
types. This concept was challenged recently when cellular organelles including …

Neurons and glia maintain central nervous system (CNS) homeostasis through diverse
mechanisms of intra-and intercellular signaling. Some of these interactions include the …

Treatment of cardiac arrest/cardiopulmonary resuscitation (CA/CPR)-induced brain injury
remains a challenging issue without viable therapeutic options. Octanoic acid (OA), a lipid …

Mitochondria play an important role as an intracellular energy plant and signaling organelle.
However, mitochondria also exist outside cells where they could mediate cell-to-cell …

Astrocytes are the major glial cell in the central nervous system. These polarized cells
possess numerous processes that ensheath the vasculature and contact synapses …

Neurodegenerative disorders, including chemotherapy-induced cognitive impairment, are
associated with neuronal mitochondrial dysfunction. Cisplatin, a commonly used …

Cell-to-cell heterogeneity drives a range of (patho) physiologically important phenomena,
such as cell fate and chemotherapeutic resistance. The role of metabolism, and particularly …