Curcumin and its anti‐colorectal cancer potential: From mechanisms of action to autophagy

A Brockmueller, V Ruiz de Porras… - Phytotherapy …, 2024 - Wiley Online Library
Colorectal cancer (CRC) development and progression, one of the most common cancers
globally, is supported by specific mechanisms to escape cell death despite chemotherapy …

Articular Cartilage Regeneration via Induced Chondrocyte Autophagy by Sustained Release of Leptin Inhibitor from Thermo‐Sensitive Hydrogel through STAT3 …

Z Huang, C Liu, G Zheng, L Zhang… - Advanced …, 2023 - Wiley Online Library
The pathophysiology of osteoarthritis (OA) is closely linked to autophagy abnormalities in
articular chondrocytes, the sole mature cell type in healthy cartilage. Nevertheless, the …

Blockade of the SRC/STAT3/BCL-2 signaling axis sustains the cytotoxicity in human colorectal cancer cell lines induced by Dehydroxyhispolon methyl ether

YC Hsieh, YC Dai, KT Cheng, WT Yang, MV Ramani… - Biomedicines, 2023 - mdpi.com
Colorectal cancer (CRC) is the third most prevalent human cancer globally. 5-Fluorouracil (5-
FU)-based systemic chemotherapy is the primary strategy for advanced CRC treatment, yet …

Heat Shock Proteins, a Double-Edged Sword: Significance in Cancer Progression, Chemotherapy Resistance and Novel Therapeutic Perspectives

D Kunachowicz, M Król-Kulikowska, W Raczycka… - Cancers, 2024 - mdpi.com
Simple Summary Among the many mechanisms developed by cancer cells in order to
survive and sustain constant proliferation under stress conditions, a system based on heat …

Precise visualization and ROS-dependent photodynamic therapy of colorectal cancer with a novel mitochondrial viscosity photosensitive fluorescent probe

R Xiao, F Zheng, K Kang, L Xiao, A Bi, Y Chen… - Biomaterials …, 2023 - spj.science.org
Background Colorectal cancer (CRC) is a prominent global cancer with high mortality rates
among human beings. Efficient diagnosis and treatment have always been a challenge for …

Curcumin suppresses colorectal tumorigenesis through restoring the gut microbiota and metabolites

W Deng, X Xiong, M Lu, S Huang, Y Luo, Y Wang… - BMC cancer, 2024 - Springer
Background Curcumin has been reported to have activity for prevention and therapy of CRC,
yet its underlying mechanisms remain largely unknown. Recently, emerging evidence …

Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism

D Yeo, YG Yun, SJ Shin, K Dashnyam… - Scientific Reports, 2024 - nature.com
Oral cancer stands as a prevalent maligancy worldwide; however, its therapeutic potential is
limited by undesired effects and complications. As a medicinal edible fungus, Chaga …

Study on the inhibition of non-small cell lung cancer mediated by chitosan-based gene carrier delivering STAT3-shRNA

W Zhang, L Song, Y Zhou, J Sun, C Li, B Han… - International Journal of …, 2024 - Elsevier
Systemic chemotherapy and radiotherapy often yield poor effect in the postoperative
treatment of non-small cell lung cancer (NSCLC) and induce drug resistance. Herein, we …

Zinc finger protein 263 promotes colorectal cancer cell progression by activating STAT3 and enhancing chemoradiotherapy resistance

Y Du, Y Chen, Z Yan, J Yang, M Da - Scientific Reports, 2024 - nature.com
Abstract Zinc finger protein 263 (ZNF263) is frequently upregulated in various tumor types;
however, its function and regulatory mechanism in colorectal cancer (CRC) have not yet …

Design, synthesis, and biological evaluation of novel (E)-2-cyano-3-(4, 9-dioxo-4, 9-dihydronaphtho [2, 3-b] furan-2-yl) derivatives as potent STAT3-targeting …

W Jiang, P Liu, Z Zhao, D Fan, X He, Y Jiang… - Bioorganic Chemistry, 2024 - Elsevier
Dysregulation of signal transducer and activator of transcription 3 (STAT3) is implicated in
the pathogenesis of various cancers, underscoring its potential as a cancer therapeutic …