Globally, the number of people with multiple co-occurring diseases will increase
substantially over the coming decades, with important consequences for patients, carers …

Background: Blood transfusion is a life-saving intervention for millions of recipients
worldwide. Over the last 15 years, the advent of high-throughput, affordable omics …

The kidneys operate at the interface of plasma and urine by clearing molecular waste
products while retaining valuable solutes. Genetic studies of paired plasma and urine …

The use of omic modalities to dissect the molecular underpinnings of common diseases and
traits is becoming increasingly common. But multi-omic traits can be genetically predicted …

Natural human knockouts of genes associated with desirable outcomes, such as PCSK9
with low levels of LDL-cholesterol, can lead to the discovery of new drug targets and …

Recently, four studies on the potential value of small-molecule metabolites by
highthroughput functional metabolomics were published in Nature Medicine (Buergel et al …

Finasteride, a 5α-reductase inhibitor used in benign prostatic hyperplasia and androgenetic
alopecia, has been associated with an increased suicidal risk, whereas it is unclear whether …

Metabolomics-based genome-wide association studies (mGWAS) are key to understanding
the genetic regulations of metabolites in complex phenotypes. We previously developed …

Decoding functional significance of small molecule metabolites Decoding functional significance
of small molecule metabolites Biomed Pharmacother. 2022 Dec 30;158:114188. doi …

In Nature Medicine, Surendran and colleagues recently reported the analysis of human
plasma metabolomic data for 913 metabolites in∼ 20,000 individuals, identifying 2,599 …