Globally, the number of people with multiple co-occurring diseases will increase
substantially over the coming decades, with important consequences for patients, carers …

Choline is essential for proper liver, muscle, brain, lipid metabolism, cellular membrane
composition and repair. Understanding genetic determinants of circulating choline …

The kidneys operate at the interface of plasma and urine by clearing molecular waste
products while retaining valuable solutes. Genetic studies of paired plasma and urine …

The use of omic modalities to dissect the molecular underpinnings of common diseases and
traits is becoming increasingly common. But multi-omic traits can be genetically predicted …

Mature red blood cells (RBCs) lack mitochondria and thus exclusively rely on glycolysis to
generate adenosine triphosphate (ATP) during aging in vivo or storage in blood banks …

Genome-wide association analyses using high-throughput metabolomics platforms have led
to novel insights into the biology of human metabolism,,,,,–. This detailed knowledge of the …

Metabolomics-based genome-wide association studies (mGWAS) are key to understanding
the genetic regulations of metabolites in complex phenotypes. We previously developed …

Abstract Major Depressive Disorder (MDD) is a common, frequently chronic condition
characterized by substantial molecular alterations and pathway dysregulations. Single …

Pancreatic ductal adenocarcinoma (PDAC) is an uncommon but highly fatal malignancy.
Identifying causal metabolite biomarkers offers an opportunity to facilitate effective risk …

The metabolomic profile of aging is complex. Here, we analyse 325 nuclear magnetic
resonance (NMR) biomarkers from 250,341 UK Biobank participants, identifying 54 …