Cumulative evidence indicates that a significant proportion of cancer evolution may occur
before the development of histological abnormalities. While recent improvements in DNA …

Colorectal cancer progression originates when accumulated genetic and epigenetic
alterations cause genomic instability and a malignant phenotype. Subsequent molecular …

Cell cycle progression and DNA synthesis are essential steps in cancer cell growth and
resistance. Thymidylate synthase (TS) is a therapeutic target for 5FU. Curcumin is a potent …

MIR-491 is commonly co-deleted with its adjacent CDKN2A on chromosome 9p21. 3 in
glioblastoma multiforme (GBM). However, it is not known whether deletion of MIR-491 is …

Older age and inadequate folate intake are strongly implicated as important risk factors for
colon cancer and each is associated with altered DNA methylation. This study was designed …

Colorectal cancer (CRC) develops as multistep process, which involves genetic and
epigenetic alterations. K-Ras, p53 and B-Raf mutations and RASSF1A, E-Cadherin and …

Background Both gastric and colorectal cancers (CRC) are the most frequently occurring
malignancies worldwide with the overall survival of these patients remains unsatisfied …

Levels of γ-aminobutyric acid (GABA) and glutamic acid decarboxylase 1 (GAD1), the
enzyme that synthesizes GABA, are significantly increased in neoplastic tissues. However …

Abstract CIP/KIP and INK4 families of Cyclin-dependent kinase inhibitors (CKIs) are well-
established cell cycle regulatory proteins whose canonical function is binding to Cyclin-CDK …

Abstract p16INK4A (p16) binds to cyclin-dependent kinase 4/6, negatively regulates cell
growth. Recent studies have led to an understanding of additional biologic functions for p16; …