Highlights•Leishmaniasis remains a neglected tropical disease, with a high unmet medical
need.•Therapeutic efficacy varies depending on the species of Leishmania parasite.•Leads …

Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

Leishmaniasis is an infectious parasitic disease that is caused by protozoa of the genus
Leishmania, a member of the Trypanosomatidae family. Leishmaniasis is classified by the …

Background: Naphthoquinones are natural pigments that are widely distributed in nature
and have important biological activities. Lawsone (2-hydroxy-1, 4-naphthoquinone) and its …

Leishmaniasis affects over 150 million people all over the world, especially in subtropical
regions. Currently used antileishmanial synthesized drugs are associated with some …

Continuing our screening program for novel anti-parasite compounds, we synthesized
seven 1, 4-naphthoquinones coupled to 1, 2, 3-triazoles, five nor-β-lapachone-based 1, 2, 3 …

Leishmaniasis is a group of vector-borne, parasitic diseases caused by over 20 species of
the protozoan Leishmania spp. The three major disease classifications, cutaneous, visceral …

Highlights•Anti-leishmanial drugs available today pose severe side effects and are not
affordable.•Identifying suitable drug target is essential for effective drug development.•Target …

Significance: Parasitic diseases affect hundreds of millions of people worldwide and
represent major health problems. Treatment is becoming extremely difficult due to the …

Visceral leishmaniasis affects people from 70 countries worldwide, mostly from Indian,
African and south American continent. The increasing resistance to antimonial, miltefosine …