The nucleus reuniens of the thalamus (RE) is a key component of an extensive network of
hippocampal and cortical structures and is a fundamental substrate for cognition. A common …

Reductionist attempts to dissect complex mechanisms into simpler elements are necessary,
but not sufficient for understanding how biological properties like reward emerge out of …

The ability to recognize information that is incongruous with previous experience is critical
for survival. Novelty signals have therefore evolved in the mammalian brain to enhance …

The hippocampus is critical for encoding declarative memory, our repository of knowledge of
who, what, where and when. Mnemonic information is processed in the hippocampus …

The hippocampal CA2 subregion has a different anatomical connectivity pattern within the
entorhino-hippocampal circuit than either the CA1 or CA3 subregion. Yet major differences …

Basic and clinical observations suggest that the caudal hypothalamus comprises a key node
of the ascending arousal system, but the cell types underlying this are not fully understood …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

The generalization of fear is an adaptive, behavioral, and physiological response to the
likelihood of threat in the environment. In contrast, the overgeneralization of fear, a cardinal …

The hippocampal CA2 region plays a key role in social memory. The encoding of such
memory involves afferent activity from the hypothalamic supramammillary nucleus (SuM) to …

The CA2 region of the hippocampus is a somewhat obscure area lacking in an
understanding of its form and function. Until recently, the CA2 has been thought of as merely …