Microfluidics and surface-enhanced Raman spectroscopy, a win–win combination?

R Panneerselvam, H Sadat, EM Höhn, A Das… - Lab on a Chip, 2022 - pubs.rsc.org
With the continuous development in nanoscience and nanotechnology, analytical
techniques like surface-enhanced Raman spectroscopy (SERS) render structural and …

Why microfluidics? Merits and trends in chemical synthesis

Y Liu, X Jiang - Lab on a Chip, 2017 - pubs.rsc.org
The intrinsic limitations of conventional batch synthesis have hindered its applications in
both solving classical problems and exploiting new frontiers. Microfluidic technology offers a …

Continuous flow chemistry: where are we now? Recent applications, challenges and limitations

FM Akwi, P Watts - Chemical communications, 2018 - pubs.rsc.org
A general outlook of the changing face of chemical synthesis is provided in this article
through recent applications of continuous flow processing in both industry and academia …

The molecular industrial revolution: automated synthesis of small molecules

M Trobe, MD Burke - Angewandte Chemie International Edition, 2018 - Wiley Online Library
Today we are poised for a transition from the highly customized crafting of specific molecular
targets by hand to the increasingly general and automated assembly of different types of …

Process analytical technologies and self-optimization algorithms in automated pharmaceutical continuous manufacturing

P Liu, H Jin, Y Chen, D Wang, H Yan, M Wu… - Chinese Chemical …, 2024 - Elsevier
The pharmaceutical industry is now paying increased attention to continuous manufacturing.
While the revolution to continuous and automated manufacturing is deepening in most of the …

Recent advances in continuous-flow organocatalysis for process intensification

C De Risi, O Bortolini, A Brandolese… - Reaction Chemistry & …, 2020 - pubs.rsc.org
Chemistry in continuous-flow continues to attract attention from the community of synthetic
organic chemists due to its now well-recognized benefits including, inter alia, quick reaction …

Recent progress in lab-on-a-chip for pharmaceutical analysis and pharmacological/toxicological test

Y Ai, F Zhang, C Wang, R Xie, Q Liang - TrAC Trends in Analytical …, 2019 - Elsevier
As one of emerging applications of lab-on-a-chip, microfluidics contribution to
pharmaceutical science has arose increasing attention. The demand of lab-on-a-chip …

Particle-based liquid chromatographic separations in microfluidic devices-a review

A Kecskemeti, A Gaspar - Analytica Chimica Acta, 2018 - Elsevier
The research and applications of liquid chromatographic (LC) chips receive more and more
attention due to the numerous advantages over the traditional and larger analytical systems …

Integration of segmented microflow chemistry and online HPLC/MS analysis on a microfluidic chip system enabling enantioselective analyses at the nanoliter scale

SK Piendl, T Schönfelder, M Polack, L Weigelt… - Lab on a Chip, 2021 - pubs.rsc.org
In this work, we introduce an approach to merge droplet microfluidics with an HPLC/MS
functionality on a single chip to analyze the contents of individual droplets. This is achieved …

High-throughput and ultrafast liquid chromatography

AS Kaplitz, GA Kresge, B Selover, L Horvat… - Analytical …, 2019 - ACS Publications
Analytical scientists working in many sectors have long expressed the need for increasingly
fast chromatographic separations. The pharmaceutical industry, for example, has a growing …