Precisely controlled cell deformations are key to cell migration, division and tissue
morphogenesis, and have been implicated in cell differentiation during development, as well …

The actin cytoskeleton consists of structurally and biochemically different actin filament
arrays. Among them, the actin cortex is thought to have key roles in cell mechanics, but …

Cytokinesis, the final step in cell division, partitions the contents of a single cell into two. In
animal cells, cytokinesis occurs through cortical remodeling orchestrated by the anaphase …

Cytokinesis mediates the physical separation of dividing cells after chromosome
segregation. In animal cell cytokinesis, a contractile ring, mainly composed of actin and …

Formins are a widely expressed family of proteins that govern cell shape, adhesion,
cytokinesis, and morphogenesis by remodeling the actin and microtubule cytoskeletons …

Protrusion formation is an essential step during cell migration. Cells migrating in three-
dimensional environments and in vivo can form a wide variety of protrusion types, including …

Formins are conserved actin polymerization machines that have instrumental roles in
controlling rearrangements of the actin cytoskeleton and have recently been shown to …

Cytokinesis is the process by which mitotic cells physically split in two following
chromosome segregation. Dividing animal cells first ingress a cytokinetic furrow and then …

Biologists have long recognized that dramatic bending of a cell sheet may be driven by even
modest shrinking of the apical sides of cells. Cell shape changes and tissue movements like …

Fission yeast cells use Arp2/3 complex and formin to assemble diverse filamentous actin (F-
actin) networks within a common cytoplasm for endocytosis, division, and polarization …