Click and bioorthogonal chemistry: the future of active targeting of nanoparticles for nanomedicines?

L Taiariol, C Chaix, C Farre, E Moreau - Chemical Reviews, 2021 - ACS Publications
Over the years, click and bioorthogonal reactions have been the subject of considerable
research efforts. These high-performance chemical reactions have been developed to meet …

Click chemistry strategies for the accelerated synthesis of functional macromolecules

Z Geng, JJ Shin, Y Xi, CJ Hawker - Journal of Polymer Science, 2021 - Wiley Online Library
Click chemistry is one of the most powerful strategies for constructing polymeric soft
materials with precise control over architecture and functionality. In this review, we provide a …

Quantum dots in biomedical applications

AM Wagner, JM Knipe, G Orive, NA Peppas - Acta biomaterialia, 2019 - Elsevier
Semiconducting nanoparticles, more commonly known as quantum dots, possess unique
size and shape dependent optoelectronic properties. In recent years, these unique …

Inverse electron demand Diels–Alder reactions in chemical biology

BL Oliveira, Z Guo, GJL Bernardes - Chemical Society Reviews, 2017 - pubs.rsc.org
The emerging inverse electron demand Diels–Alder (IEDDA) reaction stands out from other
bioorthogonal reactions by virtue of its unmatchable kinetics, excellent orthogonality and …

The surface science of nanocrystals

MA Boles, D Ling, T Hyeon, DV Talapin - Nature materials, 2016 - nature.com
All nanomaterials share a common feature of large surface-to-volume ratio, making their
surfaces the dominant player in many physical and chemical processes. Surface ligands …

Advances in chemical protein modification

O Boutureira, GJL Bernardes - Chemical reviews, 2015 - ACS Publications
Chemical protein modification has emerged as an invaluable tool for the development of
modified proteins. The complementary use of both genetic and chemical methods has …

Toward biocompatible semiconductor quantum dots: from biosynthesis and bioconjugation to biomedical application

J Zhou, Y Yang, C Zhang - Chemical reviews, 2015 - ACS Publications
The understanding of biological systems at the molecular scale is increasingly reliant on the
capability of tracking miscellaneous biomolecules and their events with improved spatial …

Colloidal nanoparticles as advanced biological sensors

PD Howes, R Chandrawati, MM Stevens - Science, 2014 - science.org
Background Nanoparticle biosensors have the potential to enhance or supersede current
analytical techniques, and their introduction could have a great impact in research and …

Click chemistry in complex mixtures: bioorthogonal bioconjugation

CS McKay, MG Finn - Chemistry & biology, 2014 - cell.com
The selective chemical modification of biological molecules drives a good portion of modern
drug development and fundamental biological research. While a few early examples of …

Cellular incorporation of unnatural amino acids and bioorthogonal labeling of proteins

K Lang, JW Chin - Chemical reviews, 2014 - ACS Publications
In the past 15 years, there have been rapid developments in the ability to cotranslationally
incorporate unnatural amino acids into proteins produced in cells, both at defined sites via …