Plasmid-acquired carbapenemases in Enterobacteriaceae, which were first discovered in
Europe in the 1990s, are now increasingly being identified at an alarming rate. Although …

Carbapenemases are β-lactamases with versatile hydrolytic capacities. They have the ability
to hydrolyze penicillins, cephalosporins, monobactams, and carbapenems. Bacteria …

The ascendancy of metallo-β-lactamases within the clinical sector, while not ubiquitous, has
nonetheless been dramatic; some reports indicate that nearly 30% of imipenem-resistant …

Gene cassettes are small mobile elements, consisting of little more than a single gene and
recombination site, which are captured by larger elements called integrons. Several …

The emergence and rapid spread of carbapenemases in Enterobacteriaceae,
Pseudomonas and Acinetobacter (EPA) species is becoming a major public health crisis …

Rapid detection of metallo-β-lactamase (MBL)-producing gram-negative pathogens is
critical to prevent their widespread dissemination. Thus far, no standardized phenotypic …

Metallo-β-lactamase enzymes (MβL) are encoded by transferable genes, which appear to
spread rapidly among gram-negative bacteria. The objective of this study was to develop a …

ABSTRACT VIM-1-producing Klebsiella pneumoniae (VPKP) is an emerging pathogen. A
prospective observational study was conducted to evaluate the importance of VIM …

For the last four years Greece has faced a large number of infections, mainly in the intensive
care units (ICU), due to carbapenem-resistant, VIM-1-producing Klebsiella pneumoniae. The …

Treatment options are limited in infections caused by extended-spectrum β-lactamase
(ESBL)-producing Enterobacteriaceae, with carbapenems generally preferred. Disturbingly …