Phosphoinositides as membrane organizers
Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …
Protein-losing enteropathy
A Ozen, MJ Lenardo - New England Journal of Medicine, 2023 - Mass Medical Soc
Protein-Losing Enteropathy | New England Journal of Medicine Skip to main content The New
England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …
England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …
PI3K isoforms in cell signalling and vesicle trafficking
B Bilanges, Y Posor, B Vanhaesebroeck - Nature reviews Molecular …, 2019 - nature.com
PI3Ks are a family of lipid kinases that phosphorylate intracellular inositol lipids to regulate
signalling and intracellular vesicular traffic. Mammals have eight isoforms of PI3K, divided …
signalling and intracellular vesicular traffic. Mammals have eight isoforms of PI3K, divided …
Beyond PI3Ks: targeting phosphoinositide kinases in disease
JE Burke, J Triscott, BM Emerling… - Nature Reviews Drug …, 2023 - nature.com
Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …
PI (3, 4) P2-mediated cytokinetic abscission prevents early senescence and cataract formation
INTRODUCTION In response to aging, senescence plays a major role in the onset of various
degenerative diseases, including the slow development of cataracts, a clouding of the eye …
degenerative diseases, including the slow development of cataracts, a clouding of the eye …
Whole-genome sequencing of European autochthonous and commercial pig breeds allows the detection of signatures of selection for adaptation of genetic resources …
Background Natural and artificial directional selection in cosmopolitan and autochthonous
pig breeds and wild boars have shaped their genomes and resulted in a reservoir of animal …
pig breeds and wild boars have shaped their genomes and resulted in a reservoir of animal …
Phosphoinositides in new spaces
EM Davies, CA Mitchell… - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
Phosphoinositides (PIs) are phospholipids derived from phosphatidylinositol. PIs are
regulated via reversible phosphorylation, which is directed by the opposing actions of PI …
regulated via reversible phosphorylation, which is directed by the opposing actions of PI …
PI3K inhibitors in thrombosis and cardiovascular disease
TN Durrant, I Hers - Clinical and Translational Medicine, 2020 - Springer
Abstract Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate important
intracellular signalling and vesicle trafficking events via the generation of 3 …
intracellular signalling and vesicle trafficking events via the generation of 3 …
Genome-wide detection of CNVs and their association with performance traits in broilers
AC Fernandes, VH da Silva, CP Goes, GCM Moreira… - BMC genomics, 2021 - Springer
Abstract Background Copy number variations (CNVs) are a major type of structural genomic
variants that underlie genetic architecture and phenotypic variation of complex traits, not …
variants that underlie genetic architecture and phenotypic variation of complex traits, not …
Structural basis of phosphatidylinositol 3-kinase C2α function
Abstract Phosphatidylinositol 3-kinase type 2α (PI3KC2α) is an essential member of the
structurally unresolved class II PI3K family with crucial functions in lipid signaling …
structurally unresolved class II PI3K family with crucial functions in lipid signaling …