Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …

Cytochrome P450 2B6 (CYP2B6) belongs to the minor drug metabolizing P450s in human
liver. Expression is highly variable both between individuals and within individuals, owing to …

Adverse drug reactions (ADRs) are one of the major causes of morbidity and mortality
worldwide. It is well-known that individual genetic make-up is one of the causative factors of …

Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug
metabolism than was previously believed. The discovery of multiple important substrates of …

Pharmacogenomics (PGx) is an integral part of precision medicine and contributes to the
maximization of drug efficacy and reduction of adverse drug event risk. Accurate information …

Efavirenz is a highly effective HIV-1 antiretroviral; however, it is also frequently associated
with neuropsychiatric adverse events (NPAE) that include abnormal dreams, sleep …

Abstract Cytochrome P450 (CYP) 2B6 belongs to the set of important hepatic drug-
metabolizing CYPs. It makes up roughly 3%–6% of total hepatic CYP content and …

This systematic review was undertaken to determine the extent to which adult subjects
representing sex (female), race (nonwhite), and age (> 50 years) categories are included in …

Idiosyncratic drug‐induced liver injury (IDILI) is a significant source of drug recall and acute
liver failure (ALF) in the United States. While current drug development processes …

Efavirenz Induced QTc Interval Prolongation Background Efavirenz (EFV) has been
associated with torsade de pointes despite marginal QT interval lengthening. Since EFV is …