Regulation of MCM2-7 function
Y Ishimi - Genes & genetic systems, 2018 - jstage.jst.go.jp
Recently published structural and functional analyses of the CMG complex have provided
insight into the mechanism of its DNA helicase function and into the distinct roles of its …
insight into the mechanism of its DNA helicase function and into the distinct roles of its …
The human replicative helicase, the CMG complex, as a target for anti-cancer therapy
YS Seo, YH Kang - Frontiers in molecular biosciences, 2018 - frontiersin.org
DNA helicases unwind or rearrange duplex DNA during replication, recombination and
repair. Helicases of many pathogenic organisms such as viruses, bacteria, and protozoa …
repair. Helicases of many pathogenic organisms such as viruses, bacteria, and protozoa …
Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication
A Ibarra, E Schwob, J Méndez - Proceedings of the …, 2008 - National Acad Sciences
The six main minichromosome maintenance proteins (Mcm2–7), which presumably
constitute the core of the replicative DNA helicase, are present in chromatin in large excess …
constitute the core of the replicative DNA helicase, are present in chromatin in large excess …
The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination
The minichromosome maintenance protein homologs MCM8 and MCM9 have previously
been implicated in DNA replication elongation and prereplication complex (pre-RC) …
been implicated in DNA replication elongation and prereplication complex (pre-RC) …
Dynamic loading and redistribution of the Mcm2‐7 helicase complex through the cell cycle
SK Powell, HK MacAlpine, JA Prinz, Y Li… - The EMBO …, 2015 - embopress.org
Eukaryotic replication origins are defined by the ORC‐dependent loading of the Mcm2‐7
helicase complex onto chromatin in G1. Paradoxically, there is a vast excess of Mcm2‐7 …
helicase complex onto chromatin in G1. Paradoxically, there is a vast excess of Mcm2‐7 …
Minichromosome maintenance proteins 2, 3 and 7 in medulloblastoma: overexpression and involvement in regulation of cell migration and invasion
KM Lau, QKY Chan, JCS Pang, KKW Li, WW Yeung… - Oncogene, 2010 - nature.com
Abstract Minichromosome maintenance (MCM) proteins 2–7 are important in DNA
replication licensing. Functional roles beyond licensing are speculated. In addition …
replication licensing. Functional roles beyond licensing are speculated. In addition …
Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress
CH Chuang, MD Wallace, C Abratte, T Southard… - PLoS …, 2010 - journals.plos.org
Mutations causing replication stress can lead to genomic instability (GIN). In vitro studies
have shown that drastic depletion of the MCM2-7 DNA replication licensing factors, which …
have shown that drastic depletion of the MCM2-7 DNA replication licensing factors, which …
Inhibition of MCM2 enhances the sensitivity of ovarian cancer cell to carboplatin
M Deng, J Sun, S Xie, H Zhen… - Molecular …, 2019 - spandidos-publications.com
Chemotherapy is widely used for the treatment of ovarian cancer. Since chemotherapy
resistance is the major cause of poor prognosis in patients with ovarian cancer, it is …
resistance is the major cause of poor prognosis in patients with ovarian cancer, it is …
Quantitative proteomics reveals dynamic interactions of the minichromosome maintenance complex (MCM) in the cellular response to etoposide induced DNA …
R Drissi, ML Dubois, M Douziech… - Molecular & Cellular …, 2015 - ASBMB
The minichromosome maintenance complex (MCM) proteins are required for processive
DNA replication and are a target of S-phase checkpoints. The eukaryotic MCM complex …
DNA replication and are a target of S-phase checkpoints. The eukaryotic MCM complex …
Ancient diversification of eukaryotic MCM DNA replication proteins
Y Liu, TA Richards, SJ Aves - BMC evolutionary biology, 2009 - Springer
Background Yeast and animal cells require six mini-chromosome maintenance proteins
(Mcm2-7) for pre-replication complex formation, DNA replication initiation and DNA …
(Mcm2-7) for pre-replication complex formation, DNA replication initiation and DNA …