Calcific aortic stenosis

BR Lindman, MA Clavel, P Mathieu, B Iung… - Nature reviews Disease …, 2016 - nature.com
Calcific aortic stenosis (AS) is the most prevalent heart valve disorder in developed
countries. It is characterized by progressive fibro-calcific remodelling and thickening of the …

Aortic-valve stenosis—from patients at risk to severe valve obstruction

CM Otto, B Prendergast - New England Journal of Medicine, 2014 - Mass Medical Soc
Aortic-Valve Stenosis — From Patients at Risk to Severe Valve Obstruction | New England Journal
of Medicine Skip to main content Access provided by Charite - Universitaetsmedizin Berlin The …

[HTML][HTML] Calcific aortic valve disease: not simply a degenerative process a review and agenda for research from the National Heart and Lung and Blood Institute Aortic …

NM Rajamannan, FJ Evans, E Aikawa… - Circulation, 2011 - ncbi.nlm.nih.gov
Calcific aortic valve disease (CAVD) encompasses the range of disease from initial
alterations in the cell biology of the leaflets to end-stage calcification resulting in left …

[HTML][HTML] Type 1 and type 2 diabetes mellitus and incidence of seven cardiovascular diseases

SC Larsson, A Wallin, N Håkansson… - International journal of …, 2018 - Elsevier
Background The association between type 1 diabetes mellitus (T1DM) and specific
cardiovascular diseases (CVD) is uncertain. Furthermore, data on type 2 diabetes mellitus …

Association between cardiovascular risk factors and aortic stenosis: the CANHEART aortic stenosis study

AT Yan, M Koh, KK Chan, H Guo, DA Alter… - Journal of the American …, 2017 - jacc.org
Background: Few longitudinal studies have delineated the association between traditional
cardiovascular risk factors and development of aortic stenosis (AS). Objectives: The authors …

Role of p38 MAPK in atherosclerosis and aortic valve sclerosis

A Reustle, M Torzewski - International journal of molecular sciences, 2018 - mdpi.com
Atherosclerosis and aortic valve sclerosis are cardiovascular diseases with an increasing
prevalence in western societies. Statins are widely applied in atherosclerosis therapy …

The regulation of valvular and vascular sclerosis by osteogenic morphogens

KI Boström, NM Rajamannan, DA Towler - Circulation research, 2011 - Am Heart Assoc
Vascular calcification increasingly afflicts our aging, dysmetabolic population. Once
considered only a passive process of dead and dying cells, vascular calcification has now …

Molecular and cellular aspects of calcific aortic valve disease

DA Towler - Circulation research, 2013 - Am Heart Assoc
Calcific aortic valve disease (CAVD) increasingly afflicts our aging population. One third of
our elderly have echocardiographic or radiological evidence of calcific aortic valve sclerosis …

Inflammation is associated with the remodeling of calcific aortic valve disease

N Coté, A Mahmut, Y Bosse, C Couture, S Pagé… - Inflammation, 2013 - Springer
Calcific aortic valve disease (CAVD) is the most frequent heart valve disorder. Studies
indicate that mineralization of the aortic valve may be related to the inflammatory process …

Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease

E Aikawa, M Nahrendorf, D Sosnovik, VM Lok… - Circulation, 2007 - Am Heart Assoc
Background—Visualizing early changes in valvular cell functions in vivo may predict the
future risk and identify therapeutic targets for prevention of aortic valve stenosis. Methods …