This review is an updated and expanded version of the three prior reviews that were
published in this journal in 1997, 2003, and 2007. In the case of all approved therapeutic …

Our ever‐increasing understanding of biological systems is providing a range of exciting
novel biological targets, whose modulation may enable novel therapeutic options for many …

Unlike natural macromolecules (eg, nucleic acids and proteins) possessing precisely
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …

This review is an updated and expanded version of two prior reviews that were published in
this journal in 1997 and 2003. In the case of all approved agents the time frame has been …

Antimicrobial peptides (AMPs) provide protection against a variety of pathogenic bacteria
and are, therefore, an important part of the innate immune system. Over the past decade …

Clinically, antibiotics are widely used to treat infectious diseases; however, excessive drug
abuse and overuse exacerbate the prevalence of drug-resistant bacterial pathogens …

Over the past decade, foldamers have progressively emerged as useful architectures to
mimic secondary structures of proteins. Peptidic foldamers, consisting of various amino acid …

Infectious diseases continue to be one of the major contributors to human morbidity. The
rapid rate at which pathogenic microorganisms have developed resistance against frontline …

In recent years, significant effort has gone into making synthetic oligomers that can attain
well-defined conformations analogous to the folding of biomolecules. The diversity of the …

Biophysical and structural investigations are presented with a focus on the membrane lipid
interactions of cationic linear antibiotic peptides such as magainin, PGLa, LL37, and melittin …