Epidemiology and management of osteoporosis in the People's Republic of China: current perspectives

X Lin, D Xiong, YQ Peng, ZF Sheng… - … interventions in aging, 2015 - Taylor & Francis
With the progressive aging of the population, osteoporosis has gradually grown into a global
health problem for men and women aged 50 years and older because of its consequences …

The role of statins in the differentiation and function of bone cells

S Chamani, L Liberale, L Mobasheri… - European journal of …, 2021 - Wiley Online Library
Abstract Background Statins are 3‐Hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA)
reductase inhibitors blocking cholesterol biosynthesis in hepatic cells, thereby causing an …

[HTML][HTML] A baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration

S Jin, J Gao, R Yang, C Yuan, R Wang, Q Zou, Y Zuo… - Bioactive materials, 2022 - Elsevier
We demonstrate a simple, effective and feasible method to address the shrinkage of Poly
(lactic-co-glycolic acid)(PLGA) through a core-shell structure fiber strategy. The results …

[HTML][HTML] Arachidonic acid impairs the function of the blood-testis barrier via triggering mitochondrial complex-ROS-P38 MAPK axis in hyperthermal Sertoli cells

Y Hu, H Hu, L Yin, L Wang, KY Luo, NJ Luo - … and Environmental Safety, 2023 - Elsevier
The death of Sertoli cells (SCs) under condition of heat stress (HS) affects spermatogenesis
and is associated with impaired function of the blood-testis barrier (BTB). The fatty acid …

Kaempferol stimulates WNT/β-catenin signaling pathway to induce differentiation of osteoblasts

AR Sharma, JS Nam - The Journal of nutritional biochemistry, 2019 - Elsevier
Flavonoids, a group of natural compounds found in a variety of vegetables and herbal
medicines, have been intensively reported on stimulating bone mineral density and bone …

Baicalin ameliorates dexamethasone-induced osteoporosis by regulation of the RANK/RANKL/OPG signaling pathway

Y Zhao, HL Wang, TT Li, F Yang… - Drug Design …, 2020 - Taylor & Francis
Background Osteoporosis is a chronic bone metabolism disorder affecting millions of the
world population. The RANKL/RANK/OPG signaling pathway has been confirmed to be the …

Canonical Wnt signaling differently modulates osteogenic differentiation of mesenchymal stem cells derived from bone marrow and from periodontal ligament under …

W Liu, A Konermann, T Guo, A Jäger, L Zhang… - Biochimica et Biophysica …, 2014 - Elsevier
Background Cellular plasticity and complex functional requirements of the periodontal
ligament (PDL) assume a local stem cell (SC) niche to maintain tissue homeostasis and …

Molecular signaling mechanisms behind polyphenol-induced bone anabolism

E Torre - Phytochemistry Reviews, 2017 - Springer
For millennia, in the different cultures all over the world, plants have been extensively used
as a source of therapeutic agents with wide-ranging medicinal applications, thus becoming …

Flavonoids induce the synthesis and secretion of neurotrophic factors in cultured rat astrocytes: a signaling response mediated by estrogen receptor

SL Xu, CWC Bi, RCY Choi, KY Zhu… - Evidence‐Based …, 2013 - Wiley Online Library
Neurotrophic factors are playing vital roles in survival, growth, and function of neurons.
Regulation of neurotrophic factors in the brain has been considered as one of the targets in …

Quercitrin and taxifolin stimulate osteoblast differentiation in MC3T3-E1 cells and inhibit osteoclastogenesis in RAW 264.7 cells

M Satué, M del Mar Arriero, M Monjo… - Biochemical Pharmacology, 2013 - Elsevier
Flavonoids are natural antioxidants that positively influence bone metabolism. The present
study screened among different flavonoids to identify biomolecules for potential use in bone …