The kidney has tremendous capacity to repair after acute injury, however, pathways guiding
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …

Tumor-associated macrophages (TAMs) are important immune cells in the tumor
microenvironment, and their invasion in tumors is closely related to poor prognosis …

Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …

The mechanisms of cardiovascular diseases (CVDs) remain incompletely elucidated. Single-
cell RNA sequencing (scRNA-seq) has enabled the profiling of single-cell transcriptomes at …

BACKGROUND With increasing significance of developmental programming effects
associated with placental dysfunction, more investigations are devoted to improving the …

The bovine mammary stem/progenitor cell secretome stimulates regeneration in vitro and
contains proteins associated with antimicrobial defense. This has led to the exploration of …

Background Mouse models have been widely used to understand kidney disease
pathomechanisms and play an important role in drug discovery. However, these models …

Single-cell RNA sequencing (scRNA-seq) technology provides a powerful tool for
understanding complex biosystems at the single-cell and single-molecule level. The past …

Single-cell RNA sequencing (scRNA-seq) has allowed for the profiling of host and virus
transcripts and host-virus interactions at single-cell resolution. This review summarizes the …

Altered lipid metabolism is a characteristic feature and potential driving factor of acute
kidney injury (AKI). Of the lipids that accumulate in injured renal tissues, ceramides are …