Sex development relies on the sex-specific action of gene networks to differentiate the
bipotential gonads of the growing fetus into testis or ovaries, followed by the differentiation of …

Primary sex determination is the decision by which the bipotential embryonic gonad commits
to either the testicular or ovarian fate. The developing gonad constitutes a unique paradigm …

The diagnosis and management of children born with ambiguous genitalia is challenging for
clinicians. Such differences of sex development (DSDs) are congenital conditions in which …

The body of knowledge surrounding reproductive development spans the fields of genetics,
anatomy, physiology and biomedicine, to build a comprehensive understanding of the later …

The elegant developmental biology experiments conducted in the 1940s by French
physiologist Alfred Jost demonstrated that the sexual phenotype of a mammalian embryo …

The medical and psychosocial challenges faced by patients living with
Disorders/Differences of Sex Development (DSD) and their families can be alleviated by a …

Missense mutations in the gene, MAP3K1, are a common cause of 46, XY gonadal
dysgenesis, accounting for 15–20% of cases [Ostrer, 2014, Disorders of sex development …

Typical sex development relies on very complex biological events, which involve specific
interactions of a large number of genes and pathways in a defined spatiotemporal …

Background: 46, XY disorders/differences of sex development (46, XY DSD) are congenital
conditions that result from abnormal gonadal development (gonadal dysgenesis) or …

WNT2B is a member of the Wnt family, a group of signal transduction proteins involved in
embryologic development and stem cell renewal and maintenance. We recently reported …