Epithelial ovarian cancer (EOC) is one of the cancers most influenced by hereditary factors.
A fourth to a fifth of unselected EOC patients carry pathogenic variants (PVs) in a number of …

Hereditary breast and ovarian cancer syndrome is caused by germline mutations in
BRCA1/2 genes. These genes are very large and their mutations are heterogeneous and …

Background: Several available data suggest the association between specific molecular
subtypes and BRCA1/2 mutational status. Previous investigations showed the association …

Simple Summary In this retrospective observational study, we evaluated data from patients
with triple-negative breast cancer (TNBC) treated with neoadjuvant chemotherapy (NACT) in …

Simple Summary The increasing number of data supporting use of a personalized approach
in cancer treatment, is changing the path of patient's management. In the same time, the …

Purpose Germline mutations of BRCA1 and BRCA2 are associated with a defined lifetime
risk of breast (BC), ovarian (OC) and other cancers. Testing BRCA genes is pivotal to assess …

Approximately 30–50% of hereditary breast and ovarian cancer (HBOC) is due to the
presence of germline pathogenic variants in the BRCA1 (OMIM 113705) and BRCA2 (OMIM …

The development of breast cancer depends on several risk factors, including environmental,
lifestyle and genetic factors. Despite the evolution of DNA sequencing techniques and …

Spinal cord injury (SCI) is characterized by a cascade of events that lead to sensory and
motor disabilities. To date, this condition is irreversible, and no cure exists. To improve …

Simple Summary Ovarian cancer (OC) is the second most common gynecologic malignancy
and the most common cause of death among women with gynecologic cancer. Despite …