In mammals, a central circadian clock, located in the suprachiasmatic nuclei (SCN) of the
hypothalamus, tunes the innate circadian physiological rhythms to the ambient 24 h light …

Melatonin, an endogenous signal of darkness, is an important component of the body's
internal time-keeping system. As such it regulates major physiological processes including …

Benzodiazepine sedative‐hypnotic drugs are widely used for the treatment of insomnia.
Nevertheless, their adverse effects, such as next‐day hangover, dependence and …

Sleep disorders have received widespread attention nowadays, which have been promoted
by the accelerated pace of life, unhealthy diets and lack of exercise in modern society. The …

A systematic review was conducted using Samueli Institute's Rapid Evidence Assessment of
the Literature (REAL©) process to determine the evidence base for melatonin as an agent to …

Melatonin, secreted nocturnally by the pineal gland, is an endogenous sleep regulator.
Impaired melatonin production and complaints on poor quality of sleep are common among …

Objective: Melatonin, the hormone produced nocturnally by the pineal gland, serves as a
circadian time cue and sleep-anticipating signal in humans. With age, melatonin production …

Several melatonin receptors agonists (ramelteon, prolonged-release melatonin,
agomelatine and tasimelteon) have recently become available for the treatment of insomnia …

Short-term sleep loss is known to cause temporary difficulties in cognition, behaviour and
health but the effects of persistent sleep deprivation on brain development have received …

The thalamus has a strong nonphotic influence on sleep, circadian rhythmicity, pineal
melatonin production, and secretion. The opening of the sleep gate for nonrapid eye …