Modeling of heterogeneous materials and media is a problem of fundamental importance to
a wide class of phenomena and systems, ranging from condensed matter physics, soft …

The cellular detail of blood is an essential factor in its flow, especially in vessels or devices
with size comparable to that of its suspended cells. This article motivates and reviews …

Understanding amazingly complex brain functions and pathologies requires a complete
cerebral vascular atlas in stereotaxic coordinates. Making a precise atlas for cerebral …

Connections between neurons are affected within 3 min of stroke onset by massive ischemic
depolarization and then delayed cell death. Some connections can recover with prompt …

Despite advances in imaging, image-based vascular systems biology has remained
challenging because blood vessel data are often available only from a single modality or at …

We present, to our knowledge, the first direct numerical simulation of 3D cellular-scale blood
flow in physiologically realistic microvascular networks. The vascular networks are designed …

Recent advances in data acquisition produce volume data of very high resolution and large
size, such as terabyte-sized microscopy volumes. These data often contain many fine and …

The topology of the cerebral vasculature, which is the energy transport corridor of the brain,
can be used to study cerebral circulatory pathways. Limited by the restrictions of the vascular …

In recent years, biological imaging techniques have advanced significantly and it is now
possible to digitally reconstruct microvascular network structures in detail, identifying the …

Elucidating connectivity and functionality at the whole-brain level is one of the most
challenging research goals in neuroscience. Various whole-brain optical imaging …