Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Histone deacetylases (HDACs)—enzymes that affect the acetylation status of histones and
other important cellular proteins—have been recognized as potentially useful therapeutic …

Cholesterol is a major constituent of the human brain, and the brain is the most cholesterol‐
rich organ. Numerous lipoprotein receptors and apolipoproteins are expressed in the brain …

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a
polyglutamine stretch in the huntingtin protein. Today, more than 15 years after the genetic …

Huntington's disease (HD), an incurable neurodegenerative disorder, has a complex
pathogenesis including protein aggregation and the dysregulation of neuronal transcription …

Huntington's Disease is an adult-onset dominant heritable disorder characterized by
progressive psychiatric disruption, cognitive deficits, and loss of motor coordination. It is …

Cholesterol is an essential component of both the peripheral nervous system and central
nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes …

Huntington's disease is an autosomal dominant neurodegenerative disease caused by
abnormal polyglutamine expansion in huntingtin (Exp-HTT) leading to degeneration of …

In contrast to their parent molecule cholesterol, two of its side-chain oxidized metabolites are
able to cross the blood–brain barrier. There is a concentration-driven flux of 24S …