Machine learning driven drug repurposing strategy for identification of potential RET inhibitors against non-small cell lung cancer

P Ramesh, R Karuppasamy, S Veerappapillai - Medical Oncology, 2022 - Springer
Non-small cell lung cancer (NSCLC) remains the leading cause of mortality and morbidity
worldwide accounting about 85% of total lung cancer cases. The receptor REarranged …

Known compounds and new lessons: structural and electronic basis of flavonoid-based bioactivities

RJ Meshram, KT Bagul, SP Pawnikar… - Journal of …, 2020 - Taylor & Francis
Flavonoids correspond to a major class of polyphenolic phytochemicals with flavone as
major parent scaffold. This class of compounds is attributed with very rich nutritional as well …

Study of the inhibition effect of two novel synthesized amido‐amine‐based cationic surfactants on aluminum corrosion in 0.5 M HCl solution

DF Seyam, A H. Tantawy, S Eid… - Journal of Surfactants …, 2022 - Wiley Online Library
Two novel amido‐amine‐based cationic surfactants, namely, 3‐decanamido‐N, N, N‐
trimethylpropan‐1‐aminium methyl sulfate (DAMS) and N‐(3‐decanamidopropyl)‐N, N …

Density functional theory molecular modeling and antimicrobial behaviour of selected 1, 2, 3, 4, 5, 6, 7, 8-octahydroacridine-N (10)-oxides

M Marinescu, LO Cinteza, GI Marton… - Journal of Molecular …, 2017 - Elsevier
Abstract A series of 9-substituted 1, 2, 3, 4, 5, 6, 7, 8-octahydroacridine-N (10)-oxides is
evaluated against 12 bacterial and fungal strains, for their microbicidal and anti-pathogenic …

High throughput screening against pantothenate synthetase identifies amide inhibitors against Mycobacterium tuberculosis and Staphylococcus aureus

S Pradhan, C Sinha - In Silico Pharmacology, 2018 - Springer
Pantothenate is a crucial enzyme for the synthesis of coenzyme A and acyl carrier protein in
Mycobacterium tuberculosis and Staphylococcus aureus. It is indispensable for the growth …

Effect of the Persian Gulf Brittle Star (Ophiocoma erinaceus) dichloromethane extract on induction of apoptosis on EL4 Cell Line

M Afzali, J Baharara, K Shahrokhabadi… - Journal of Rafsanjan …, 2015 - journal.rums.ac.ir
Materials and Methods: In this laboratory study, the lymphoma cells were cultured in RPMI
1640 medium. After 24 h, cells were treated with different concentrations (7.5, 15, 31, 62 …

[HTML][HTML] Производные тиурониевых солей на основе вицинальных диаминов как потенциальные нейропротекторы

НА Лозинская, АА Морозов, ДР Базанов… - Безопасность и риск …, 2023 - cyberleninka.ru
Применяемые в клинической практике лекарственные средства для лечения
нейродегенеративных заболеваний, в частности болезни Альцгеймера, в основном …

[HTML][HTML] Antitumor activity of methyl (Z)-2-(isothioureidomethyl)-2-pentenoate hydrobromide against leukemia cell lines via mitotic arrest and apoptotic pathways

LS Assunção, IF Kretzer, JAS Restrepo… - … et Biophysica Acta (BBA …, 2019 - Elsevier
In a previous study, we described a series of 28 aryl-and alkyl-substituted isothiouronium
salts with antitumor activity and selectivity toward a leukemia cell line. Among the …

New uranium (vi) and isothiouronium complexes: synthesis, crystal structure, spectroscopic characterization and a DFT study

E Grabias, B Tarasiuk, A Dołęga, M Majdan - CrystEngComm, 2020 - pubs.rsc.org
The crystal structures of S, S′-2, 5-dimethylbenzene-1, 4-diylbis (methylisothiouronium)
diacetate (1_ac), S, S′-2, 5-dimethylbenzene-1, 4-diylbis (methylisothiouronium) dichloride …

[图书][B] Data mining methods for the prediction of intestinal absorption using QSAR

DA Newby - 2014 - search.proquest.com
Oral administration is the most common route for administration of drugs. With the growing
cost of drug discovery, the development of Quantitative Structure-Activity Relationships …