[HTML][HTML] Normothermic liver machine perfusion as a dynamic platform for regenerative purposes: What does the future have in store for us?

B Lascaris, VE de Meijer, RJ Porte - Journal of Hepatology, 2022 - Elsevier
Liver transplantation has become an immense success; nevertheless, far more recipients
are registered on waiting lists than there are available donor livers for transplantation. High …

Viability testing during liver preservation

D Patrono, C Lonati, R Romagnoli - Current Opinion in Organ …, 2022 - journals.lww.com
MP adds a further element of complexity in the process of assessing the quality of a liver
graft. Understanding the physiology of the parameters included in the different assessment …

Strategies to improve the utilization and function of DCD livers

SC Kim, DP Foley - Transplantation, 2024 - journals.lww.com
Despite the increased usage of livers from donation after circulatory death (DCD) donors in
the last decade, many patients remaining on the waitlist who need a liver transplant. Recent …

[HTML][HTML] Biliary viability assessment and treatment options of biliary injury during normothermic liver perfusion—a systematic review

J Dingfelder, L Rauter, GA Berlakovich… - Transplant …, 2022 - frontierspartnerships.org
In recent years, significant progress has been made in the field of liver machine perfusion.
Many large transplant centers have implemented machine perfusion strategies in their …

Two compartment evaluation of liver grafts during acellular room temperature machine perfusion (acRTMP) in a rat liver transplant model

N Abraham, M Zhang, P Cray, Q Gao, KP Samy… - Frontiers in …, 2022 - frontiersin.org
Background Subnormothermic machine perfusion (SNMP) of liver grafts is currently less
clinically developed than normothermic and hypothermic approaches, but may have …

Quality assessment by bile composition in normothermic machine perfusion of rat livers

V Muth, F Stobl, J Michelotto, L Gilles… - … Engineering Part A, 2024 - liebertpub.com
Background: The persistent challenge of organ scarcity in liver transplantation leads to an
escalating dependence on organs obtained from extended criteria donors (ECD) …

An extensive evaluation of hepatic markers of damage and regeneration in controlled and uncontrolled donation after circulatory death

G Basta, F Melandro, S Babboni, S Del Turco… - Liver …, 2023 - journals.lww.com
Livers from donations after circulatory death (DCDs) are very sensitive to
ischemia/reperfusion injury and thus need careful reconditioning, such as normothermic …

[HTML][HTML] Assessment of Mitochondrial Respiration During Hypothermic Storage of Liver Biopsies Following Normothermic Machine Perfusion

J Hofmann, A Kofler, M Schartner… - Transplant …, 2024 - frontierspartnerships.org
Organ quality can be assessed prior to transplantation, during normothermic machine
perfusion (NMP) of the liver. Evaluation of mitochondrial function by high-resolution …

Experimental & Clinical Applications of Ex Vivo Liver Perfusion

JJ Hefler - 2023 - era.library.ualberta.ca
Normothermic machine perfusion (NMP) is a novel method of organ preservation that has
recently risen in prominence. NMP involves the maintenance of an organ outside the body in …

Is Hepatocyte Necrosis a Good Marker of Donor Liver Viability During Machine Perfusion?

DAH Neil, H Mergental, A Hann, RW Laing… - Hepatology …, 2022 - journals.lww.com
We read with interest the paper by Kesseli et al.,(1) which uses a primate nontransplant
model to assess markers of nonviability of donation after circulatory death (DCD) livers …