Protein-based adjuvants for vaccines as immunomodulators of the innate and adaptive immune response: Current knowledge, challenges, and future opportunities

DA Díaz-Dinamarca, ML Salazar, BN Castillo… - Pharmaceutics, 2022 - mdpi.com
New-generation vaccines, formulated with subunits or nucleic acids, are less immunogenic
than classical vaccines formulated with live-attenuated or inactivated pathogens. This …

[HTML][HTML] Evolution of molluscan hemocyanin structures

J Markl - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2013 - Elsevier
Hemocyanin transports oxygen in the hemolymph of many molluscs and arthropods and is
therefore a central physiological factor in these animals. Molluscan hemocyanin molecules …

Binding isotope effects

K Swiderek, P Paneth - Chemical reviews, 2013 - ACS Publications
These include radioactivity of 3H, 14C, and 35S or NMR activity of 1H, 13C, and 15N to
name those most frequently employed in chemical studies. The above examples may be …

Antimicrobial activity of molluscan hemocyanins from Helix and Rapana snails

P Dolashka, A Dolashki, JV Beeumen… - Current …, 2016 - ingentaconnect.com
For the first time the antimicrobial activities of hemocyanins from the molluscs Rapana
venosa (RvH) and Helix aspersa (HaH) have been tested. From the hemolymph of the …

An 1H NMR- and MS-Based Study of Metabolites Profiling of Garden Snail Helix aspersa Mucus

NG Vassilev, SD Simova, M Dangalov, L Velkova… - Metabolites, 2020 - mdpi.com
Metabolic profiling based on 1H nuclear magnetic resonance (NMR) spectroscopy was
applied with the aim to investigate the functional role of the metabolites in lyophilized mucus …

[PDF][PDF] Bioactive compounds isolated from garden snails.

P Dolashka, A Dolashki, L Velkova… - Journal of BioScience …, 2015 - researchgate.net
Bioactive compounds isolated from garden snails Page 1 ISSN: 1314-6246 Dolashka et al. J.
BioSci. Biotechnol. 2015, SE/ONLINE: 147-155 RESEARCH ARTICLE SPECIAL EDITION …

N-Glycosylation of mollusk hemocyanins contributes to their structural stability and immunomodulatory properties in mammals

ML Salazar, JM Jiménez, J Villar, M Rivera… - Journal of Biological …, 2019 - ASBMB
Hemocyanins are widely used as carriers, adjuvants, and nonspecific immunostimulants in
cancer because they promote Th1 immunity in mammals. Hemocyanins also interact with …

Hemocyanins from Helix and Rapana Snails Exhibit in Vitro Antitumor Effects in Human Colorectal Adenocarcinoma

A Georgieva, K Todorova, I Iliev, V Dilcheva, I Vladov… - Biomedicines, 2020 - mdpi.com
Hemocyanins are oxygen-transporting glycoproteins in the hemolymph of arthropods and
mollusks that attract scientific interest with their diverse biological activities and potential …

Gene expression and phenoloxidase activities of hemocyanin isoforms in response to pathogen infections in abalone Haliotis diversicolor

T Yao, MM Zhao, J He, T Han, W Peng, H Zhang… - International journal of …, 2019 - Elsevier
Hemocyanins (Hc), the main protein components of hemolymph in invertebrates, are not
only involved in oxygen transport but also linked to non-specific immune responses. In this …

N-glycan structures of β-HlH subunit of Helix lucorum hemocyanin

L Velkova, P Dolashka, J Van Beeumen… - Carbohydrate …, 2017 - Elsevier
The carbohydrate structures of molluscan hemocyanins have recently received particular
interest due to their specific monosaccharide composition, as well as their …