Summary The China Kadoorie Biobank (CKB) is a population-based prospective cohort of>
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …

Simple Summary Several risk prediction tools have been developed to better stratify women
according to their risk of developing breast cancer (BC) and inform prevention and early …

Breast cancer (BC) is the most common malignancy in American women.*, 1 Mortality has
declined, in part because screening detects cancers at an early stage. 2 For most women …

We performed genome-wide association studies of breast cancer including 18,034 cases
and 22,104 controls of African ancestry. Genetic variants at 12 loci were associated with …

Background: The multifactorial risk prediction model BOADICEA enables identification of
women at higher or lower risk of developing breast cancer. BOADICEA models genetic …

Purpose The benefit of using individual risk prediction tools to identify high-risk individuals
for breast cancer (BC) screening is uncertain, despite the personalized approach of risk …

Abstract Background Previous work in European ancestry populations has shown that
adding a polygenic risk score (PRS) to breast cancer risk prediction models based on …

Importance Polygenic risk scores (PRSs) have shown promise in breast cancer risk
prediction; however, limited studies have been conducted among Asian women. Objective …

Background Despite the rising incidence and mortality of breast cancer among women in
China, there are currently few predictive models for breast cancer in the Chinese population …

The 313-variant polygenic risk score (PRS 313) provides a promising tool for breast cancer
risk prediction. However, evaluation of the PRS 313 across different European populations …