Since the early days of foundational studies of nucleic acids, many chemical moieties have
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …

Abstract N 6-methyl-2′-deoxyadenosine (6mA or m6dA) has been reported in the DNA of
prokaryotes and eukaryotes ranging from unicellular protozoa and algae to multicellular …

METTL4 belongs to a subclade of MT-A70 family members of methyltransferase (MTase)
proteins shown to mediate N 6-adenosine methylation for both RNA and DNA in diverse …

Abstract N6-methyladenosine (m6A) is the most abundant internal RNA modification in
eukaryotic mRNAs and influences many aspects of RNA processing. miCLIP (m6A …

The field of RNA modification, also referred to as “epitranscriptomics,” is gaining more and
more interest from the scientific community. More than 160 chemical modifications have …

DNA modifications are used to regulate gene expression and defend against invading
genetic elements. In eukaryotes, modifications predominantly involve C5-methylcytosine …

Most organs in the body rely on blood flow, and vesicular damage is the leading cause of
injury in multiple organs. The endothelium, as the barriers of vessels, play a critical role in …

Summary In eukaryotes, N6‐methyladenosine (m6A) is abundant on mRNA, and plays key
roles in the regulation of RNA function. However, the roles and regulatory mechanisms of …

N4-acetylcytidine (ac4C) is an ancient and conserved RNA modification. Previously, ac4C
mRNA modification has been reported promoting proliferation and metastasis of tumor cells …

Non-coding RNAs (ncRNAs) account for the majority of the widespread transcripts of
mammalian genomes. They rarely encode proteins and peptides, but their regulatory role is …