Inflammation in obesity, diabetes, and related disorders

TV Rohm, DT Meier, JM Olefsky, MY Donath - Immunity, 2022 - cell.com
Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Metabolic syndrome: updates on pathophysiology and management in 2021

G Fahed, L Aoun, M Bou Zerdan, S Allam… - International journal of …, 2022 - mdpi.com
Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin
resistance, atherogenic dyslipidemia, central obesity, and hypertension. The pathogenesis …

Acarbose treatment affects the serum levels of inflammatory cytokines and the gut content of bifidobacteria in C hinese patients with type 2 diabetes mellitus: 阿卡波糖 …

B Su, H Liu, J Li, Y Sunli, B Liu, D Liu… - Journal of …, 2015 - Wiley Online Library
摘要背景: 研究对中国2 型糖尿病患者在常规治疗的基础上加用阿卡波糖后对患者粪便肠道菌群
及血清炎症因子的影响. 方法: 95 名2 型糖尿病患者在常规治疗的基础上随机分为两组, A 组59 …

Global impacts of western diet and its effects on metabolism and health: A narrative review

VJ Clemente-Suárez, AI Beltrán-Velasco… - Nutrients, 2023 - mdpi.com
The Western diet is a modern dietary pattern characterized by high intakes of pre-packaged
foods, refined grains, red meat, processed meat, high-sugar drinks, candy, sweets, fried …

IL-6 in inflammation, autoimmunity and cancer

T Hirano - International immunology, 2021 - academic.oup.com
IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

The menace of obesity to depression and anxiety prevalence

S Fulton, L Décarie-Spain, X Fioramonti… - Trends in Endocrinology …, 2022 - cell.com
The incidence of depression and anxiety is amplified by obesity. Mounting evidence reveals
that the psychiatric consequences of obesity stem from poor diet, inactivity, and visceral …

An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH

F Tacke, T Puengel, R Loomba, SL Friedman - Journal of Hepatology, 2023 - Elsevier
Successful development of treatments for non-alcoholic fatty liver disease and its
progressive form, non-alcoholic steatohepatitis (NASH), has been challenging. Because …

Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

The metabolic nature of inflammatory bowel diseases

TE Adolph, M Meyer, J Schwärzler, L Mayr… - Nature Reviews …, 2022 - nature.com
Crohn's disease and ulcerative colitis, phenotypically comprising a spectrum of inflammatory
bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary …

High-fat, western-style diet, systemic inflammation, and gut microbiota: a narrative review

IJ Malesza, M Malesza, J Walkowiak, N Mussin… - Cells, 2021 - mdpi.com
The gut microbiota is responsible for recovering energy from food, providing hosts with
vitamins, and providing a barrier function against exogenous pathogens. In addition, it is …