Calreticulin (CRT), when localized to the endoplasmic reticulum (ER), has important
functions in directing proper conformation of proteins and glycoproteins, as well as in …

The response to exogenous pathogens leads to activation of innate immunity through the
release of pathogen-associated molecular patterns (PAMPs) and their binding to pattern …

Thrombospondin 1 (TSP1) is a matricellular extracellular matrix protein that has diverse
roles in regulating cellular processes important for the pathogenesis of fibrotic diseases. We …

A corona is a layer of macromolecules formed on a nanoparticle surface in vivo. It can
substantially change the biological identity of nanomaterials and possibly trigger adverse …

Background Cardiac fibrosis attributed to excessive deposition of extracellular matrix
proteins is a major cause of heart failure and death. Cardiac fibrosis is extremely difficult and …

Fibroblasts are key cellular mediators of many chronic interstitial lung diseases, including
idiopathic pulmonary fibrosis, scleroderma, sarcoidosis, drug-induced interstitial lung …

Endoplasmic reticulum (ER) stress is an emerging factor in fibrotic disease, although precise
mechanisms are not clear. Calreticulin (CRT) is an ER chaperone and regulator of Ca 2+ …

Annexin A1, a well-known endogenous anti-inflammatory mediator, plays a critical role in a
variety of pathological processes. Fibrosis is described by a failure of tissue regeneration …

The myeloproliferative neoplasms are associated with chronic kidney disease but whether
clonal haematopoiesis of indeterminate potential (CHIP) is associated with impaired kidney …

Urine has the potential to become a better source of biomarkers. Urinary proteins are
affected by many factors; therefore, differentiating between the variables associated with any …