Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

Chromatin folds into dynamic loops that often span hundreds of kilobases and physically
wire distant loci together for gene regulation. These loops are continuously created …

Abstract Topologically Associating Domains (TADs) separate vertebrate genomes into
insulated regulatory neighborhoods that focus genome-associated processes. TADs are …

Cohesin and CCCTC-binding factor (CTCF) are key regulatory proteins of three-dimensional
(3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a …

Mammalian chromosomes are organized at different length scales within the cell nucleus.
Topologically Associating Domains (TADs) are structural units of 3D genome organization …

Histone deacetylase 8 (HDAC8) is a class I HDAC that catalyzes the deacetylation of histone
and non-histone proteins. As one of the best-characterized isoforms, numerous studies have …

Cohesin folds the genome in dynamic chromatin loops and holds the sister chromatids
together. NIPBL Scc2 is currently considered the cohesin loader, a role that may need …

Cohesin connects CTCF-binding sites and other genomic loci in cis to form chromatin loops
and replicated DNA molecules in trans to mediate sister chromatid cohesion. Whether …

In the early stages of mitosis, cohesin is released from chromosome arms but not from
centromeres. The protection of centromeric cohesin by SGO1 maintains the sister chromatid …

Genomic instability arising from defective responses to DNA damage or mitotic
chromosomal imbalances can lead to the sequestration of DNA in aberrant extranuclear …