[HTML][HTML] Systems biology approaches integrated with artificial intelligence for optimized metabolic engineering
Metabolic engineering aims to maximize the production of bio-economically important
substances (compounds, enzymes, or other proteins) through the optimization of the …
substances (compounds, enzymes, or other proteins) through the optimization of the …
The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys
L Jiao, Y Yang, W Yu, Y Zhao, H Long, J Gao… - Signal transduction and …, 2021 - nature.com
Neurological manifestations are frequently reported in the COVID-19 patients.
Neuromechanism of SARS-CoV-2 remains to be elucidated. In this study, we explored the …
Neuromechanism of SARS-CoV-2 remains to be elucidated. In this study, we explored the …
A high-resolution genome-wide CRISPR/Cas9 viability screen reveals structural features and contextual diversity of the human cell-essential proteome
T Bertomeu, J Coulombe-Huntington… - … and cellular biology, 2018 - Taylor & Francis
To interrogate genes essential for cell growth, proliferation and survival in human cells, we
carried out a genome-wide clustered regularly interspaced short palindromic repeat …
carried out a genome-wide clustered regularly interspaced short palindromic repeat …
Metrics for the Human Proteome Project 2016: progress on identifying and characterizing the human proteome, including post-translational modifications
The HUPO Human Proteome Project (HPP) has two overall goals:(1) stepwise completion of
the protein parts list the draft human proteome including confidently identifying and …
the protein parts list the draft human proteome including confidently identifying and …
Systematic analysis of alternative exon-dependent interactome remodeling reveals multitasking functions of gene regulatory factors
Alternative splicing significantly expands biological complexity, particularly in the vertebrate
nervous system. Increasing evidence indicates that developmental and tissue-dependent …
nervous system. Increasing evidence indicates that developmental and tissue-dependent …
Weakly supervised learning of RNA modifications from low-resolution epitranscriptome data
Motivation Increasing evidence suggests that post-transcriptional ribonucleic acid (RNA)
modifications regulate essential biomolecular functions and are related to the pathogenesis …
modifications regulate essential biomolecular functions and are related to the pathogenesis …
Assessing the functional relevance of splice isoforms
F Pozo, L Martinez-Gomez, TA Walsh… - NAR Genomics and …, 2021 - academic.oup.com
Alternative splicing of messenger RNA can generate an array of mature transcripts, but it is
not clear how many go on to produce functionally relevant protein isoforms. There is only …
not clear how many go on to produce functionally relevant protein isoforms. There is only …
Multi-attention multiple instance learning
AV Konstantinov, LV Utkin - Neural Computing and Applications, 2022 - Springer
A new multi-attention based method for solving the MIL problem (MAMIL), which takes into
account the neighboring patches or instances of each analyzed patch in a bag, is proposed …
account the neighboring patches or instances of each analyzed patch in a bag, is proposed …
Isoform function prediction based on bi-random walks on a heterogeneous network
Motivation Alternative splicing contributes to the functional diversity of protein species and
the proteoforms translated from alternatively spliced isoforms of a gene actually execute the …
the proteoforms translated from alternatively spliced isoforms of a gene actually execute the …
Differentiating isoform functions with collaborative matrix factorization
Motivation Isoforms are alternatively spliced mRNAs of genes. They can be translated into
different functional proteoforms, and thus greatly increase the functional diversity of protein …
different functional proteoforms, and thus greatly increase the functional diversity of protein …