[HTML][HTML] Chronic low back pain, bacterial infection and treatment with antibiotics

CJ Gilligan, SP Cohen, VA Fischetti, JA Hirsch… - The Spine Journal, 2021 - Elsevier
The contribution of bacterial infection to chronic low back pain and its treatment with
antibiotics have generated considerable controversy in literature. If efficacious, antibiotics …

The association between low virulence organisms in different locations and intervertebral disc structural failure: A meta‐analysis and systematic review

X Chen, S Lu, N Chopra, P Cui, S Zhang, R Narulla… - Jor …, 2023 - Wiley Online Library
Many factors may trigger intervertebral disc (IVD) structural failure (intervertebral disc
degeneration (IDD) and endplate changes), including inflammation, infection, dysbiosis, and …

Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre …

LCH Bråten, MP Rolfsen, A Espeland, M Wigemyr… - bmj, 2019 - bmj.com
Objective To assess the efficacy of three months of antibiotic treatment compared with
placebo in patients with chronic low back pain, previous disc herniation, and vertebral …

Propionibacterium acnes infected intervertebral discs cause vertebral bone marrow lesions consistent with Modic changes

S Dudli, E Liebenberg, S Magnitsky… - Journal of …, 2016 - Wiley Online Library
Modic type I change (MC1) are vertebral bone marrow lesions adjacent to degenerated
discs that are specific for discogenic low back pain. The etiopathogenesis is unknown, but …

ISSLS PRIZE IN CLINICAL SCIENCE 2017: Is infection the possible initiator of disc disease? An insight from proteomic analysis

S Rajasekaran, C Tangavel, SN Aiyer… - European spine …, 2017 - Springer
Study design Proteomic and 16S rDNA analysis of disc tissues obtained in vivo. Objective
To address the controversy of infection as an aetiology for disc disorders through protein …

Propionibacterium acnes, coagulase-negative Staphylococcus, and the “biofilm-like” intervertebral disc

MF Coscia, GA Denys, MF Wack - Spine, 2016 - journals.lww.com
Study Design. Patients scheduled for spinal surgery were screened prospectively for a
microbial presence associated with intervertebral disc specimens. Inclusion was limited to …

Evidence for infection in intervertebral disc degeneration: a systematic review

I Granville Smith, NP Danckert, MB Freidin… - European Spine …, 2022 - Springer
Purpose Back pain is a major problem worldwide and is linked to intervertebral disc
degeneration and Modic change. Several studies report growth of bacteria following …

Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the TLR2/JNK/mitochondrial-mediated pathway

Y Lin, Y Jiao, Y Yuan, Z Zhou, Y Zheng… - Emerging microbes & …, 2018 - Taylor & Francis
Evidence suggests that intervertebral disc degeneration (IVDD) can be induced by
Propionibacterium acnes (P. acnes), although the underlying mechanisms are unclear. In …

Association between chronic inflammation and latent infection of Propionibacterium acnes in non-pyogenic degenerated intervertebral discs: a pilot study

Y Yuan, Y Chen, Z Zhou, Y Jiao, C Li, Y Zheng… - European Spine …, 2018 - Springer
Purpose Propionibacterium acnes may be considered a new pathogeny for disc
degeneration, but its pathological role has remained unclear. This study was designed to …

Histological Identification of Propionibacterium acnes in Nonpyogenic Degenerated Intervertebral Discs

Y Yuan, Z Zhou, Y Jiao, C Li, Y Zheng… - BioMed research …, 2017 - Wiley Online Library
Purpose. Low‐virulence anaerobic bacteria, especially the Propionibacterium acnes (P.
acnes), have been thought to be a new pathogeny for a series of disc diseases. However …