Baking soda and vinegar have been used as home remedies for generations and today we
are only a mouse-click away from claims that baking soda, lemon juice, and apple cider …

Kidneys are central in the regulation of multiple physiological functions, such as removal of
metabolic wastes and toxins, maintenance of electrolyte and fluid balance, and control of pH …

The Cl−-transporting proteins CFTR, SLC26A9, and anoctamin (ANO1; ANO6) appear to
have more in common than initially suspected, as they all participate in the pathogenic …

Bicarbonate is one of the major anions in mammalian tissues and fluids, is utilized by
various exchangers to transport other ions and organic substrates across cell membranes …

Background: In cystic fibrosis (CF), renal base excretion is impaired. Accordingly,
challenged urine bicarbonate excretion may be an in vivo biomarker of cystic fibrosis …

Aim Cystic fibrosis patients have an increased risk of developing metabolic alkalosis
presumably as a result of altered renal HCO3− handling. In this study, we directly assess the …

The kidney plays a crucial role in acid-base homeostasis. In the distal nephron, α-
intercalated cells contribute to urinary acid (H+) secretion and β-intercalated cells …

This review summarizes the newly discovered molecular mechanism of secretin‐stimulated
urine HCO3–excretion and the role of cystic fibrosis transmembrane conductance regulator …

Abstract Pendrin (SLC26A4) is an anion exchanger from the SLC26 transporter family which
is mutated in human patients affected by Pendred syndrome, an autosomal recessive …

The kidney plays a key role in the correction of systemic acid-base imbalances. Central for
this regulation are the intercalated cells in the distal nephron, which secrete acid or base …