The epithelial-to-mesenchymal transition as a possible therapeutic target in fibrotic disorders

J Di Gregorio, I Robuffo, S Spalletta… - Frontiers in cell and …, 2020 - frontiersin.org
Fibrosis is a chronic and progressive disorder characterized by excessive deposition of
extracellular matrix, which leads to scarring and loss of function of the affected organ or …

Mechanisms of TGFβ-induced epithelial–mesenchymal transition

A Moustakas, CH Heldin - Journal of clinical medicine, 2016 - mdpi.com
Transitory phenotypic changes such as the epithelial–mesenchymal transition (EMT) help
embryonic cells to generate migratory descendants that populate new sites and establish …

Mechanisms of peritoneal fibrosis: focus on immune cells–peritoneal stroma interactions

M Terri, F Trionfetti, C Montaldo, M Cordani… - Frontiers in …, 2021 - frontiersin.org
Peritoneal fibrosis is characterized by abnormal production of extracellular matrix proteins
leading to progressive thickening of the submesothelial compact zone of the peritoneal …

Molecular pathways in peritoneal fibrosis

MS Balzer - Cellular signalling, 2020 - Elsevier
Peritoneal dialysis (PD) is a renal replacement therapy for patients with end-stage renal
disease that is equivalent to hemodialysis with respect to adequacy, mortality, and other …

Molecular mechanisms underlying peritoneal EMT and fibrosis

R Strippoli, R Moreno-Vicente, C Battistelli… - Stem cells …, 2016 - Wiley Online Library
Peritoneal dialysis is a form of renal replacement alternative to the hemodialysis. During this
treatment, the peritoneal membrane acts as a permeable barrier for exchange of solutes and …

Carcinoma‐associated fibroblasts derive from mesothelial cells via mesothelial‐to‐mesenchymal transition in peritoneal metastasis

P Sandoval, JA Jiménez‐Heffernan… - The Journal of …, 2013 - Wiley Online Library
Peritoneal dissemination is a frequent metastatic route for cancers of the ovary and
gastrointestinal tract. Tumour cells metastasize by attaching to and invading through the …

Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology

C Derada Troletti, RD Fontijn, E Gowing… - Cell death & …, 2019 - nature.com
The blood-brain barrier (BBB) has a major role in maintaining brain homeostasis through the
specialized function of brain endothelial cells (BECs). Inflammation of the BECs and loss of …

Mesothelial‐to‐mesenchymal transition in the pathogenesis of post‐surgical peritoneal adhesions

P Sandoval, JA Jiménez‐Heffernan… - The Journal of …, 2016 - Wiley Online Library
Peritoneal adhesions (PAs) are fibrotic bands formed between bowel loops, solid organs,
and the parietal peritoneum, which may appear following surgery, infection or …

Caveolin‐1 deficiency induces a MEK‐ERK 1/2‐Snail‐1‐dependent epithelial–mesenchymal transition and fibrosis during peritoneal dialysis

R Strippoli, J Loureiro, V Moreno… - EMBO molecular …, 2015 - embopress.org
Peritoneal dialysis (PD) is a form of renal replacement therapy whose repeated use can alter
dialytic function through induction of epithelial–mesenchymal transition (EMT) and fibrosis …

Mesenchymal conversion of mesothelial cells is a key event in the pathophysiology of the peritoneum during peritoneal dialysis

M López-Cabrera - Advances in medicine, 2014 - Wiley Online Library
Peritoneal dialysis (PD) is a therapeutic option for the treatment of end‐stage renal disease
and is based on the use of the peritoneum as a semipermeable membrane for the exchange …