Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in
antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent …

Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different
pathophysiological processes in the atria. Some aspects of the morphological and …

For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …

NADPH oxidases of the Nox family exist in various supergroups of eukaryotes but not in
prokaryotes, and play crucial roles in a variety of biological processes, such as host defense …

Increased oxidative stress plays an important role in the pathophysiology of cardiovascular
diseases such as hypertension, atherosclerosis, diabetes, cardiac hypertrophy, heart failure …

NADPH oxidases (NOXs) form a family of electron-transporting membrane enzymes whose
main function is reactive oxygen species (ROS) generation. Strong evidence suggests that …

The NADPH oxidase of professional phagocytes is a crucial component of the innate
immune response due to its fundamental role in the production of reactive oxygen species …

In recent years, it has become clear that reactive oxygen species (ROS, which include
superoxide, hydrogen peroxide, and other metabolites) are produced in biological systems …

Background—Atrial fibrillation (AF) is associated with an increased risk of stroke due almost
exclusively to emboli from left atrial appendage (LAA) thrombi. Recently, we reported that AF …