Atomic force microscopy-based mechanobiology

M Krieg, G Fläschner, D Alsteens, BM Gaub… - Nature Reviews …, 2019 - nature.com
Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

How Caenorhabditis elegans Senses Mechanical Stress, Temperature, and Other Physical Stimuli

MB Goodman, P Sengupta - Genetics, 2019 - academic.oup.com
Caenorhabditis elegans lives in a complex habitat in which they routinely experience large
fluctuations in temperature, and encounter physical obstacles that vary in size and …

Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation

G Cabré, A Garrido-Charles, M Moreno… - Nature …, 2019 - nature.com
Manipulation of neuronal activity using two-photon excitation of azobenzene photoswitches
with near-infrared light has been recently demonstrated, but their practical use in neuronal …

Microfluidics for understanding model organisms

N Frey, UM Sönmez, J Minden, P LeDuc - Nature communications, 2022 - nature.com
New microfluidic systems for whole organism analysis and experimentation are catalyzing
biological breakthroughs across many fields, from human health to fundamental biology …

A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing

N Sanfeliu-Cerdán, F Català-Castro, B Mateos… - Nature Cell …, 2023 - nature.com
A growing body of work suggests that the material properties of biomolecular condensates
ensuing from liquid–liquid phase separation change with time. How this aging process is …

Neural engineering with photons as synaptic transmitters

M Porta-de-la-Riva, AC Gonzalez, N Sanfeliu-Cerdán… - Nature …, 2023 - nature.com
Neuronal computation is achieved through connections of individual neurons into a larger
network. To expand the repertoire of endogenous cellular communication, we developed a …

A high-throughput behavioral screening platform for measuring chemotaxis by C. elegans

E Fryer, S Guha, LE Rogel-Hernandez… - Plos …, 2024 - journals.plos.org
Throughout history, humans have relied on plants as a source of medication, flavoring, and
food. Plants synthesize large chemical libraries and release many of these compounds into …

An asymmetric mechanical code ciphers curvature-dependent proprioceptor activity

R Das, LC Lin, F Català-Castro, N Malaiwong… - Science …, 2021 - science.org
A repetitive gait cycle is an archetypical component within the behavioral repertoire of many
animals including humans. It originates from mechanical feedback within proprioceptors to …

Volumetric imaging of fast cellular dynamics with deep learning enhanced bioluminescence microscopy

LF Morales-Curiel, AC Gonzalez… - Communications …, 2022 - nature.com
Bioluminescence microscopy is an appealing alternative to fluorescence microscopy,
because it does not depend on external illumination, and consequently does neither …

Automated and controlled mechanical stimulation and functional imaging in vivo in C. elegans

Y Cho, DA Porto, H Hwang, LJ Grundy, WR Schafer… - Lab on a Chip, 2017 - pubs.rsc.org
C. elegans is a useful genetic model system for investigating mechanisms involved in
sensory behavior which are potentially relevant to human diseases. While utilities of …